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Gabapentin is an anticonvulsive medication that received approval from the US Food and Drug Administration (FDA) in 1993 and has been available in generic form in the USA since 2004. Gabapentin was originally used as a muscle relaxant and an anti-spasmodic. However, it was later discovered that gabapentin has the potential of an anticonvulsive medication and can be used as an adjunct to more One study found that breast cancer patients taking Gabapentin for anxiety felt significant improvement and relief after four weeks. Some research notes that the effects of Gabapentin are often evident within one week, but it can take up to a month before complete relief is felt. Gabapentin is frequently used in the treatment of anxiety disorders. However, there are no randomized controlled trials on the effectiveness of this medication in generalized anxiety disorder (GAD), and there are only a few case reports. The aim of this study was to compare the effect of 3 treatment arms (placebo, gabapentin 300mg daily, gabapentin 900mg daily) on anxiety at 4 weeks and 8 weeks, respectively. Therefore, the primary efficacy variable was defined as the mean anxiety score at 4 weeks and 8 weeks, respectively. Our preliminary observations suggest a role for gabapentin as monotherapy or for adjunctive use in patients with panic disorder or generalized anxiety disorder. The promising preliminary results encourage further clinical exploration and systematic study of gabapentin for the treatment of anxiety disorders. A third study found that gabapentin may help with anxiety related to public speaking . There are also several trials of gabapentin showing efficacy in perioperative anxiety ( 61 ). Gabapentin has similar adverse effects as pregabalin including sedation, dry mouth, constipation, weight gain, and pedal edema. A clear pattern of remission or mild anxiety on total daily doses of gabapentin ≥ 900 mg/day and severe anxiety at doses < 600 mg/day was observed. In the absence of randomized controlled trials, these findings may offer clinically important clues about dosing and effectiveness of gabapentin in GAD. As the search for effective anxiety treatments continues, gabapentin has emerged as a potential ally in the battle against this pervasive mental health condition. This anticonvulsant medication, primarily used to treat epilepsy and neuropathic pain, has garnered increasing attention from researchers and clinicians for its possible anxiolytic Studies have shown that Gabapentin can be the effective for fighting anxiety. In one study, researchers tested a daily gabapentin dose of 300mg and 900mg daily in women who experienced medical anxiety. The doses of gabapentin improved anxiety symptoms significantly after 4 weeks. Multiple studies have shown pregabalin’s effectiveness in reducing symptoms of GAD, with one large meta-analysis finding that it is as effective as benzodiazepines and SSRIs in treating anxiety but with a lower risk of dependence. Visual inspection of a funnel plot for gabapentin versus placebo in preoperative anxiety suggested possible small study effects, with greater effect size being observed in high-dose gabapentin studies with smaller samples (Supplementary Appendix, Fig. 5.1). Our preliminary observations suggest a role for gabapentin as monotherapy or for adjunctive use in patients with panic disorder or generalized anxiety disorder. The promising preliminary results encourage further clinical exploration and systematic study of gabapentin for the treatment of anxiety disorders. This review will focus on the comparative properties of gabapentin and pregabalin, specifically the available evidence on their use in the treatment of primary anxiety disorders — GAD, social anxiety disorder, panic disorder, and obsessive-compulsive disorder. In another study of 16 bipolar I and II patients receiving adjunctive gabapentin (mean dose of 1,310 mg/d), 8 showed improved depression, anxiety, and irritability symptoms at 12-week follow-up. 34 Sokolski et al 35 noted in an open-label add-on trial (n = 10) that gabapentin was effective, with improvement in depressive symptoms, mania ratings Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use disorder. There is sufficient evidence to consider gabapentin as a third-line treatment for social anxiety disorder and severe panic disorder. While studies don’t typically show effectiveness for improving symptoms of depression, there is evidence that gabapentin may have some benefit for anxiety disorders. A rat study found that gabapentin produced behavioral changes suggestive of anxiolysis, or feelings of calmness. We conducted a systematic review and meta-analysis of the evidence for three of their common psychiatric uses: bipolar disorder, anxiety, and insomnia. Fifty-five double-blind randomised We call on NICE to re-evaluate their support for use of pregabalin in anxiety in light of its known harms. The use of gabapentinoids off-label for other psychiatric conditions should also be re-considered. In general, psychotropic medications require longer term efficacy and safety studies before allowing widespread use. Research and interest in Gabapentin began in the 1990s for anxiety disorders due to its unique GABAergic mechanism of action. Nearly every published study has found Gabapentin to be superior in efficacy for the reduction of anxiety when compared to a placebo. Although evidence is limited, some studies show gabapentin can help with anxiety symptoms. One 2020 review suggests gabapentin may help with different types of situational
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