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Gabapentin may decrease arterial BP in cats with and without CKD and these findings should be taken into account when gabapentin is administered to patients in which measurement of BP is needed. Visits to the veterinary clinic can be a source of stress for both the feline patient and the caregiver. Conclusions and relevance Cats with CKD that received 10 mg/kg of gabapentin had significantly higher dose-normalized serum concentrations than normal cats that received 20 mg/kg, supporting the need to dose-reduce in this patient population. Cats with chronic kidney disease (CKD) exhibit higher serum concentrations of gabapentin, indicating a need for dose adjustment. It’s essential to administer lower doses to avoid potential toxicity and monitor their response closely. The question of whether gabapentin is safe for cats with chronic kidney disease (CKD) is complex and requires careful consideration. The short answer is: it can be safe when used judiciously, but it’s not without risks and requires dosage adjustments due to the kidneys’ role in its elimination. Twenty-two cats with chronic renal failure (median age, 15.5 years) received meloxicam for a median treatment duration of 467 days, with titration to the lowest effective dose. The results suggested that a long-term daily dose of 0.02 mg/kg can be safely administered to some clinically stable cats over 7 years of age even in the presence of The 20 mg/kg stress-reduction dose of gabapentin may be beneficial to facilitate preventive veterinary care in younger, healthy cats, but this dose may be inappropriate for elderly cats, specifically those with chronic kidney disease (CKD). Compliance scores for cats with CKD were significantly increased at 3h versus 8h. Cats with higher serum gabapentin concentrations were more compliant at the 3h mark. No CKD cats were considered to be overly sedated at the 10mg/kg dose. One limitation of this study was that all of the healthy cats were fairly young compared to the CKD cats so Abstract Simple Summary. Adjusting drug dosages in dogs and cats with chronic kidney disease (CKD) can be challenging in clinical practice due to the lack of specific indications in the current literature; moreover, the evaluation of renal function through the measurement of glomerular filtration rate (GFR), which is unanimously considered as a requisite for most adjustment strategies, is Human studies have recommended Gabapentin doses be reduced in CKD patients, but no studies have been done in cats. Cats with CKD may need a reduced gabapentin dose to avoid excessive sedation. Cats with chronic kidney disease (CKD) may experience a build-up of waste products and other compounds in their bloodstream, which healthy kidneys would usually remove or regulate. Investigating appropriate dosing for gabapentin sedation in cats with and without chronic kidney disease (2017) Winn Feline Foundation reports on the study's goals and Gabapentin sedation in cats with and without chronic kidney disease (2020) Winn Feline Foundation gives an update, stating that CKD cats seem to have much higher levels of Gabapentin and Kidney Disease. It’s essential to exercise caution when using gabapentin in cats with chronic kidney disease (CKD). Higher doses can lead to excessive sedation and hypotension in these patients. A dose decrease of at least 50% is often used in these cases. It’s imperative to consult with your veterinarian if your cat has CKD. Objectives: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. Methods: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8 1. Is gabapentin safe for cats with kidney disease? Yes, gabapentin is considered safe for use in cats with kidney disease when dosed appropriately and monitored closely by a veterinarian. 2. Will gabapentin interact with other medications my cat is taking? In cats, gabapentin is most often used as a pain medication for chronic pain, such as from arthritis. Gabapentin is also recognized as beneficial in reducing the fear responses that a kitty may have to the stress of handling and being examined at the vet. Study demonstrates that companion cats with chronic kidney disease (CKD) will exhibit compliance during veterinary visits on a lower dosage of gabapentin.
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