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The question of whether gabapentin is safe for cats with chronic kidney disease (CKD) is complex and requires careful consideration. The short answer is: it can be safe when used judiciously, but it’s not without risks and requires dosage adjustments due to the kidneys’ role in its elimination. Abstract Simple Summary. Adjusting drug dosages in dogs and cats with chronic kidney disease (CKD) can be challenging in clinical practice due to the lack of specific indications in the current literature; moreover, the evaluation of renal function through the measurement of glomerular filtration rate (GFR), which is unanimously considered as a requisite for most adjustment strategies, is Conclusions and relevance Cats with CKD that received 10 mg/kg of gabapentin had significantly higher dose-normalized serum concentrations than normal cats that received 20 mg/kg, supporting the need to dose-reduce in this patient population. What dose should we use, and can we use this daily in cats? What about in cats with chronic kidney failure? In this podcast, we discuss if transdermal gabapentin can be safely used in cats, and how to administer dose this capsule. Is gabapentin bad for cats with kidney disease? Cats with chronic kidney disease (CKD) exhibit higher serum concentrations of gabapentin, indicating a need for dose adjustment. It’s essential to administer lower doses to avoid potential toxicity and monitor their response closely. Gabapentin is eliminated almost entirely through renal excretion, and decreased renal function significantly influences the pharmacokinetics of gabapentin in humans. 14 While doses of gabapentin in the range of 50–150 mg/cat have been used in normal cats, 4,5,11 it should be noted that higher doses may be unsuitable for cats with CKD. 15 In a Higher doses of gabapentin can be problematic for cats with chronic kidney disease. A 50% dose reduction or more is typically recommended. Your vet should adjust the dosage accordingly if kidney disease is present. What is the recommended gabapentin dosage for cats with kidney disease? While the standard dosage for healthy cats is 20mg/kg, cats with chronic kidney disease (CKD) should be given a reduced dose of 10mg/kg. The 20 mg/kg stress-reduction dose of gabapentin may be beneficial to facilitate preventive veterinary care in younger, healthy cats, but this dose may be inappropriate for elderly cats, specifically those with chronic kidney disease (CKD). MT17-002: Investigating appropriate dosing for gabapentin sedation in cats with and without chronic kidney disease. (An EveryCat-funded grant project, final published report) (An EveryCat-funded grant project, final published report) 1. Is gabapentin safe for cats with kidney disease? Yes, gabapentin is considered safe for use in cats with kidney disease when dosed appropriately and monitored closely by a veterinarian. 2. Will gabapentin interact with other medications my cat is taking? In addition, cats with CKD had significantly higher sedation scores than normal cats. Given the renal elimination of gabapentin and its altered pharmacokinetics in CKD, 15 together these data support cautious use at the lowest necessary dose in this patient population. Investigating appropriate dosing for gabapentin sedation in cats with and without chronic kidney disease (2017) Winn Feline Foundation reports on the study's goals and Gabapentin sedation in cats with and without chronic kidney disease (2020) Winn Feline Foundation gives an update, stating that CKD cats seem to have much higher levels of Study demonstrates that companion cats with chronic kidney disease (CKD) will exhibit compliance during veterinary visits on a lower dosage of gabapentin. Investigating appropriate dosing for gabapentin sedation in cats with and without chronic kidney disease (2017) Winn Feline Foundation reports on the study's goals and Gabapentin sedation in cats with and without chronic kidney disease (2020) Winn Feline Foundation gives an update, stating that CKD cats seem to have much higher levels of Gabapentin should be used cautiously in cats with liver or kidney disease, as we may see it take longer for the effects to wear off. Its use should typically be avoided in pregnant queens. Gabapentin is often prescribed in lower amounts for patients with kidney disease because the drug levels could rise if the renal system does not clear it out properly. One reason for renal failure or renal scarcity is kidney disease. This begs the question as to why doctors would risk diseased cats with higher doses. Objectives: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. Methods: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8 Sixteen chronic kidney disease (CKD cats) – (ten IRIS Stage 2, twelve IRIS Stage 3) – have completed the limited sampling PK study at 10 mg/kg. Samples from eight CKD cats have been analyzed to date to test the model. The model performed well and the data for normal cats demonstrated that half-life was similar to previous published reports. Gabapentin is not metabolized or protein bound, and is cleared only by renal excretion in humans; it is unknown whether this is also true in cats. 7 In humans, it has been demonstrated that kidney disease significantly influences the pharmacokinetics (PK) of gabapentin, and a 60% and 85% decrease in gabapentin clearance is seen in moderate and
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