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Gabapentin appears to be effective for reducing hot flashes, although potentially not as effective as estrogen therapy. A 2019 review and meta-analysis in the American Journal of Gabapentin (Neurontin, Gralise, others). This antiseizure medicine helps ease hot flashes. Side effects can include being drowsy, dizzy or tired and swelling in the arms and legs, called edema. Pregabalin (Lyrica). This is another anti-seizure medicine that can help ease hot flashes. Three cases are presented here suggesting that insomnia due to nighttime awakenings in some cycling premenopausal women may be physiologically related to menopausal night sweats and may also improve with bedtime gabapentin, a treatment known to be effective for hot flashes and night sweats. Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses. HOT FLASHES & NIGHT SWEATS. There are only a few studies of gabapentin and pregabalin for hot flashes and night sweats. The studies were not ideal. But, they found that these drugs decreased hot flashes more than placebo and about the same as antidepressants and estrogen pills. Hot flashes decreased by 1-3 per day more than placebo. earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and HRT is the current go-to treatment for menopausal hot flashes. Gabapentin offers non-hormonal relief and reduction in hot flashes and night sweats. The hot flashes almost stopped completely after just 1 week of taking this medicine. The study lasted for 6 months, and then I was taken off cold turkey. The withdrawal was horrible. Hot flashes, couldn't sleep, and just overall irritable to say the least. I went to my regular doctor and was prescribed gabapentin 600mg. Again the hot flashes Gabapentin for menopausal symptoms Menopause is a normal event, but some women have troublesome symptoms such as hot flushes and night sweats. The most effective treatment is menopausal hormone therapy (MHT). Gabapentin is a non-hormonal treatment that may be prescribed for women who need, or want, to avoid MHT. Government of Western Australia Menopausal hormone therapy is the most effective tool for treating hot flashes and night sweats associated with menopause. It also can help to prevent osteoporosis. "This new medication shouldn't replace hormone therapy," says Dr. Kling. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep Step-wise approach to management of menopausal hot flashes. M ANAGEMENT. The management of HFs is guided by their frequency and severity. The severity of HFs can be graded as (a) mild (no interference with usual daily activities), (b) moderate (interfere with usual daily activities to some extent), and (c) severe (when usual daily activities cannot be performed).[]
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