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The North American Menopause society and the American College of Obstetricians and Gynecologists recommend the use of gabapentin as an option for managing hot flashes in women who are unwilling to take estrogen-containing supplements. earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and Although the FDA has not approved Neurontin for hot flashes, there’s some good evidence that it’s effective. A study from the University of Rochester showed that gabapentin was effective in reducing hot flashes in patients with a damaged hypothalamus, and there have been over 20 studies on menopausal women that show similar results. Gabapentin is a drug that doctors sometimes prescribe off-label to reduce hot flashes during menopause. Instead of affecting hormones, experts think it may act on the hypothalamus, the part of This article reviews the evidence for the use of non-hormonal pharmacologic therapies for the treatment of menopausal symptoms including antidepressants, gabapentinoids, clonidine and anticholinergics. We also review data on emerging therapies including the latest evidence on neurokinin-1 and -3 antagonists. The mainstay of treatment includes hormonal replacement therapy, selective serotonin, and norepinephrine reuptake inhibitors in addition to lifestyle modification. In this review, we address common issues related to menopause HFs and suggest a stepwise approach to their management. K EYWORDS: Hormone replacement therapy, hot flashes, menopause The mean age of menopause is 51.4 years (SD, 3.3 years), and natural menopause occurs between the ages of 45 years and 56 years in 90% of women. 1 Premature hypoestrogenism (loss of estrogen before the time of natural menopause due to primary ovarian insufficiency, surgical oophorectomy, or medication-induced menopause) refers to menopause Gabapentin. Gabapentin is an anticonvulsant (an analogue of gamma-aminobutyric acid). It is approved to treat neurological disorders such as seizures and neuropathic pain. Research: A systematic review has confirmed that Gabapentin 900mg per day reduces hot flushes more effectively than placebo 11. The most common side effect of gabapentin is The present review included 21 trials conducted in 8 countries (Canada, China, Ecuador, Egypt, India, Iran, Italy, and the United States). The quality of evidence comparing gabapentin with placebo rated from very low to moderate. The quality of the evidence between gabapentin and estrogen and antidepressants were graded from very low to low. Gabapentin offers several benefits for those dealing with hot flashes, making it a viable alternative to traditional treatments. Reduction in Frequency and Severity. One of the key benefits of Gabapentin is its ability to significantly reduce the frequency and severity of hot flashes. Effective doses: Even low doses can be effective. Gabapentin has an average rating of 8.7 out of 10 from a total of 111 reviews for the off-label treatment of Hot Flashes. 87% of reviewers reported a positive experience, while 8% reported a negative experience. Randomised controlled trials (RCTs) that compared the efficacy and tolerability of gabapentin with placebo for treating hot flashes (or hot flushes) in women with either natural or tamoxifen-induced menopause were eligible for inclusion.
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