Perioperative gabapentin may reduce the incidence and intensity of postoperative pain up to 6 months after otolaryngology, orthopedic, mastectomy, and abdominal/pelvic operations. 12-15 Professional guidelines advocate for perioperative administration of gabapentin as a component of multimodal analgesia, 16 but its efficacy in the context of Purpose Gabapentin has demonstrated analgesic effects in some studies. This double blind randomized clinical trial (RCT) was conducted to evaluate whether the pre-emptive use of gabapentin 600 mg could reduce postoperative pain, nausea and vomiting, and meperidine consumption in patients after hysterectomy. Methods Between 2009 and 2010, a total of 170 patients who were candidates for We designed this double-blind, placebo-controlled study to test and compare the preventive effects of perioperative ketamine and gabapentin on early and chronic pain after elective hysterectomy. Pre-emptive use of gabapentin 600 mg orally, significantly decreases postoperative pain and PONV, and also rescues analgesic and anti emetic drug requirements in patients who undergo abdominal hysterectomy. Preemptive medication strategies (eg, medications given to the patient before surgery), including paracetamol and acetaminophen, gabapentin, nonsteroidal antiinflammatory drugs, and COX-2 inhibitors, have been shown to decrease total narcotic requirements and improve postoperative pain and satisfaction scores in women undergoing total abdominal A recent systematic review found that pre-emptive administration of gabapentin for abdominal hysterectomy was effective in reducing post-operative pain, opioid consumption and side effects and has been used in one gynecologic enhanced recovery program . However, studies have not yet identified the optimal dose, or timing of administration. One of the methods for controlling postoperative pain is preemptive analgesia. Gabapentin and tramadol are both used for this purpose. This study aims to compare the effects of tramadol and gabapentin, as premedication, in decreasing the pain after hysterectomy. Gabapentinoids were also ineffective in preventing chronic pain from developing after surgery, one of the primary justifications for using the drugs postoperatively. We investigated, in a randomized, placebo-controlled, double-blind study, the efficacy and safety of gabapentin on pain after abdominal hysterectomy and on tramadol consumption in patients. The 50 patients were randomized to receive either oral placebo or gabapentin 1200 mg 1 h before surgery. Overall, when choosing a preemptive nonnarcotic medication to control pain after abdominal hysterectomy, this review supports the use of an NSAID, COX-2 inhibitor, gabapentin, and/or paracetamol. Intravenous paracetamol is an effective preemptive therapy compared with placebo at improving pain scores, improving patient satisfaction, and Gilron I, Orr E, Tu D, et al. A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy. Pain. 2005;113:191–200. Postoperative pain is an important factor affecting anesthesia and surgery. The present study assessed the effects of 1200 mg gabapentin, an anticonvulsant drug that acts through voltage-dependent calcium channels, for the control of postoperative pain in patients undergoing abdominal hysterectomy. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathic pain as well as postoperative pain following spinal surgery and hysterectomy. In a recent nationwide shift, surgeons have sought to decrease postoperative opioid prescribing by adopting the use of non-opioid ‘multimodal’ pain regimens. 1–4 Gabapentinoids (gabapentin and pregabalin) are now commonly administered during the postoperative period for many surgical patients, especially with the rise in adoption of Gabapentin and ketamine are popular analgesic adjuvants for improving perioperative pain management. We designed this double-blind, placebo-controlled study to test and compare the preventive effects of perioperative ketamine and gabapentin on early and chronic pain after elective hysterectomy. Pain scores after abdominal hysterectomy were reduced more with gabapentin alone (preoperative dosing) than when gabapentin was given both preoperatively and postoperatively. The benefits of gabapentin for minimally invasive hysterectomy (MIH) are not as well defined. Pain scores after abdominal hysterectomy were reduced more with gabapentin alone (preoperative dosing) than when gabapentin was given both preoperatively and postoperatively. The benefits of gabapentin for minimally invasive hysterectomy (MIH) are not as well defined. Gabapentin reduced the need for additional postoperative pain treatment (PCA boluses of 50 microg of fentanyl) by 40% during the first 20 postoperative hours. Effects of gabapentin on postoperative pain, nausea and vomiting after abdominal hysterectomy: a double blind randomized clinical trial Arch Gynecol Obstet. 2012; 285 :677-682 Crossref Gabapentin and local anaesthetics may decrease postoperative pain and analgesic needs. The aim of the study was to investigate the effect of the combination of these drugs on the analgesic needs as well as on acute and late pain after abdominal hysterectomy.
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