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Gabapentin can be considered effective in the treatment of hot flashes and should be considered a reasonable alternative when estrogen therapy is not desired. Hot flashes occur frequently in menopausal women and in women with breast cancer, diminishing their quality of life. ClinicalTrialsgov [homepage on the Internet] Study of gabapentin extended release (G-ER) in the treatment of vasomotor (hot flashes/hot flushes) symptoms in postmenopausal women US National Institutes of Health; 2008[updated February 21, 2012; cited month/dd/yyyy]. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Gabapentinhas undergone investigation for treating hot flashes, after patients taking it for other indications incidentally noted improvement of hot flashes. Although it is an analogue of gamma-aminobutyric acid (GABA) and is used to treat neurologic disorders such as seizures and neuropathic pain, gabapentin does not affect Evidence from several randomized controlled trials supports the effectiveness of oxybutynin in treating hot flashes, showing reduction in hot flash frequency by up to 70% to 86%. Oxybutynin is an effective treatment for overactive bladder symptoms, which can increase in hypoestrogenic states. Comparisons of gabapentin and placebo revealed reductions of 20% to 30% in the frequency and severity of hot flashes with gabapentin, although data across the studies were too heterogeneous to provide a reliable summary effect. Clusterings of dizziness/unsteadiness and fatigue/somnolence were the mo Gabapentin presents a promising option for managing hot flashes, particularly for those who haven’t found relief through other treatments. By understanding its benefits, potential side effects, and proper administration, you can make informed decisions about its use. Background: Various nonhormonal agents have been used for the treatment of hot flashes in women with natural or tamoxifen-induced menopause. Some studies have reported that gabapentin appears to be an effective and well-tolerated treatment modality. Randomised controlled trials (RCTs) that compared the efficacy and tolerability of gabapentin with placebo for treating hot flashes (or hot flushes) in women with either natural or tamoxifen-induced menopause were eligible for inclusion. Although a double-blind placebo-controlled clinical trial should be conducted to better elucidate the efficacy and toxicity of gabapentin in patients with hot flashes, the available data suggest that gabapentin is a reasonable treatment to consider in patients with hot flashes if they do not wish to use hormonal therapy. Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses. Keywords: Estrogen, gabapentin, hot flash, menopause. Gabapentin is a drug that doctors sometimes prescribe off-label to reduce hot flashes during menopause. Instead of affecting hormones, experts think it may act on the hypothalamus, the part Based on the anecdotal information, the current phase 2 clinical trial was developed to more definitively evaluate gabapentin's efficacy against hot flashes and its associated toxicity. This study population consisted of a subset of patients who completed an original randomized, double blind phase III trial comparing gabapentin with placebo for the treatment of hot flashes in men 10. Eligible men for the original study had a history of prostate cancer and troublesome hot flashes, and were on stable androgen deprivation therapy This review investigated the efficacy and tolerability of gabapentin for the treatment of hot flashes in menopausal women. Gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women, but there was substantial variation in the results across the included trials. The authors' conclusions appear to be reliable based on the evidence presented. The following search terms were used: "menopause," "hot flushes," "vasomotor symptoms," "gabapentin," and "non-hormonal therapy." Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and dropout rate. Fortunately, a new treatment option may be able to treat hot flashes without the risk. Gabapentin, an anticonvulsant, may be effective for the treatment of hot flashes. Often sold as Neurontin, gabapentin is approved by the Food and Drug Administration (FDA) for the treatment of epilepsy. In studies, gabapentin reduced hot flashes from 45%-71% depending on the dose. In one, albeit small, clinical trial 2,400 mg of gabapentin divided three times a day was as effective as 0.625 mg of Premarin a day (which is a standard dose for hot flashes). A 2005 study by Pandya et al. randomized 420 women with breast cancer and experiencing at least 2 hot flashes in 24 hours to one of three groups: gabapentin 300 mg daily, gabapentin 900 mg daily, or placebo 23. After 8 weeks, the 300 mg dose group showed a modest 20% reduction in hot flashes, but the 900 mg dose group showed a reduction of Menopausal hormone therapy is the most effective tool for treating hot flashes and night sweats associated with menopause. It also can help to prevent osteoporosis. "This new medication shouldn't replace hormone therapy," says Dr. Kling. "Hormone therapy remains the most effective treatment for hot flashes and night sweats.
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