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Gabapentin, an anxiolytic drug that is also used off-label to treat alcohol withdrawal, is a potential candidate for modulating benzodiazepine withdrawal. Addition of an anticonvulsant (e.g., gabapentin [Neurontin]) should be considered for high-dosage withdrawal. Chronic use of a benzodiazepine can cause physiologic dependence and the potential for a withdrawal syndrome upon rapid discontinuation. Benzodiazepine dependance can develop from use of prescribed, illicit (ie, non-prescribed use of compounds used medically), and designer (ie, compounds not used medically) agents. Hi. It's a gabapentinoid and doesn't work the same way as benzos. Tolerance comes quickly on gabapentin and also, of course, comes with it's own wd problems. But if not taking it every day but only when it's really needed, both those two problems could be minimised. I wouldn't start taking gabapentin on daily basis for the two reasons above. People might also react to their conditions in a habitual emotional way, such as expressing shame or fear of withdrawal-induced symptoms, meta-emotions that compound the unexpected, unpleasant withdrawal sensations and send them into emotional spirals. 182,183 This emotionality is not a psychiatric disorder, but it confuses clinicians, who have Benzodiazepine-induced hippocampal CA1 neuron alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid (AMPA) receptor plasticity linked to severity of withdrawal anxiety: differential role of voltage-gated calcium channels and N-methyl-D-aspartic acid receptors. Different mechanisms underlying the efficacy of gabapentin in benzodiazepine withdrawal can be considered. Although it has no direct effect on GABA receptors or transporters, it has some GABA-ergic activity, which may be sufficient to compensate the benzodiazepine-related GABA activity. Very small studies and case reports have shown that drugs such as gabapentin, carbamazepine, and propranolol may help as aids in withdrawal. Trazodone, mirtazapine, and quetiapine may be helpful in some for insomnia. I also wanted to add that magnesium can interfere with gabapentin absorption. So for those taking gabapentin or thinking about it for benzo withdrawal, remember to take the magnesium (and calcium) at least 2 hrs before any gabapentin. I'm taking gabapentin right now and it seems to help the taper, OP, but I also like magnesium before bed. Gabapentin has growing evidence to support its use in the treatment of alcohol use disorder, however there is limited evidence regarding its role in the treatment of alcohol withdrawal. The purpose of this study was to determine if adjunctive gabapentin reduces the need for benzodiazepine (BZD) administration during alcohol withdrawal. Gabapentin, an anxiolytic drug that is also used off-label to treat alcohol withdrawal, is a potential candidate for modulating benzodiazepine withdrawal. Having family and/or friends who can provide help with daily tasks, understanding of the symptoms and emotional support is very important in this process. Please take time to educate family members about benzodiazepine withdrawal and how they can help their loved one through this difficult season in their life. 9. Do not fear the internet. Yes Researchers found a total daily dose of 600 mg to 1,800 mg of gabapentin reduced withdrawal symptoms. Additionally, they reported no complications with the combination of gabapentin and Gabapentin will mask benzo withdrawal symptoms. That may seem like a good thing, but when you finally reduce/eliminate the gabapentin, the benzo withdrawal symptoms may still be there. And/or gabapentin withdrawal may occur. It's difficult to tell the difference. In 2021, the American Psychiatric Association presented a study on the possibility of treating benzodiazepine dependence, abuse, and withdrawal with gabapentin. According to the psychiatrists, the two drugs share similar mechanisms, making gabapentin an effective adjunct treatment. Then I relapsed on benzos just to get off the gabapentin. For the last time quitting, I simply did a slow valium taper with daily micro reductions. That wasn't hard for me, just slow. I do think benzo withdrawal induced symptoms can go away as you taper -- some people do cut and hold and wait until the symptoms aren't bad. It helps a ton with a lot of the shitty parts of benzo withdrawal but won’t completely take the withdrawal away. At high doses of gabapentin you might not even be able to tell you’re in withdrawal anymore but be careful I’ve had high doses induce a seizure while in withdrawal. Also make sure to stagger your gabapentin doses for best results. The American Society of Addiction Medicine (ASAM) recommends gabapentin for treating withdrawal symptoms as follows: (I) Gabapentin is an appropriate alternative to benzodiazepines for mild to moderate alcohol withdrawal. Wanted to see what opinions were on taking gabapentin for the crippling anxiety that comes with benzo withdrawals. I’ve real a couple of success stories where it helped a couple of patients with PAWS and then I’ve also read where the gabapentin didn’t work. Also heard it was a drug that might be
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