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Based on the anecdotal information, the current phase 2 clinical trial was developed to more definitively evaluate gabapentin's efficacy against hot flashes and its associated toxicity. A phase III randomized, double-blind, placebo-controlled trial of gabapentin in the management of hot flashes in men (N00CB). Ann Oncol 20 (3): 542-9, 2009. [PUBMED Abstract] Mao JJ, Bowman MA, Xie SX, et al.: Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial. Given this promising evidence and the similar treatment benefits of some drugs for hot flashes in men and women, it was hypothesized that gabapentin would be effective against hot flashes in men receiving androgen ablation therapy. hot flushes in men with prostate cancer. Urol2000;55:97–101. 9. Loprinzi CL, Barton DL, Sloan JA, et al. Pilot evaluation of gabapentin for the alleviation of hot flashes. Proc ASCO 2002;362a (abst 1444). 10. Quella SK, Loprinzi CL, Sloan JA, et al. Pilot evaluation of venlafaxine for the treatment of hot flashes in men undergoing A phase III randomized, double-blind, placebo-controlled trial of gabapentin in the management of hot flashes in men (N00CB). Ann Oncol 2009;20:542-549. Crossref To evaluate the efficacy and safety of gabapentin for the treatment of hot flashes in women with menopause and/or breast cancer, we performed a search of the MEDLINE database (1966-March 2008) and International Pharmaceutical Abstracts, as well as manually searching reference articles for relevant articles and abstracts; 10 clinical studies Hot flashes are a complication of androgen deprivation therapy given to men with prostate cancer. A previous clinical study indicated that use of low dose gabapentin (900mg/day) was well-tolerated and decreased hot flash frequency to a moderate degree for 4 weeks. These results support that gabapentin decreases hot flashes, to a moderate degree, in men with androgen ablation-related vasomotor dysfunction. For men, the phenomenon of hot flashes often occurs as a result of medical or surgical treatment for prostate cancer. Although up to 75% of men treated with androgen deprivation therapy may experience hot flashes, there are limited therapeutic options for the treatment of hot flashes [18 – 20]. Examining individual trials, the two trials that evaluated 900 mg/d of gabapentin reported that hot flashes were decreased by 45% to 50% (Fig 1E). 15,16 In the individual patient trial that studied 2,400 mg/d, hot flashes were reported to be reduced by approximately 80% (Fig 1E). 17 In this last trial, however, there was a much more substantial Gabapentin is a drug that doctors sometimes prescribe off-label to reduce hot flashes during menopause. Instead of affecting hormones, experts think it may act on the hypothalamus, the part Pandya KJ, Morrow GR, Roscoe JA, et al. Gabapentin for hot flashes in 420 women with breast cancer: a randomized double blind placebo-controlled trial. Lancet 2005; 366:818–24. DOI 10.1016/S0140-6736(05)67215-7 It also noted that the anticonvulsant gabapentin is the best studied and potentially most effective of the nonhormonal treatment options. It’s important to know that testosterone replacement In a recently published clinical trial in men with prostate cancer who were treated with GnRH analogues and antiandrogens, the disabling hot flashes were successfully treated with gabapentin. 32 Unfortunately, gabapentin has been associated with anorgasmy in both men and women. 33 Nonetheless, a thorough study of gabapentin in rigorous clinical Conclusions: Gabapentin appears to provide moderate efficacy as a nonhormonal option for longer-term treatment of hot flashes in men undergoing androgen ablation for prostate cancer and seems to be well tolerated. Facts that support that gabapentin moderately decreases hot flashes in men include a statistically significant comparison of hot flash frequencies and a trend for improvement in hot flash scores between the 900 mg/day and placebo arms; statistically significant improvements of hot flash frequencies and scores between the 900 mg/day and 300 mg Men originally receiving the placebo or lowest dose of gabapentin (300 mg/d) had improved hot flash control relative to that at the end of the randomized phase. Minimal adverse effects were reported. These findings suggest that low-dose gabapentin is moderately efficacious for at least 12 weeks of hot flash treatment in men undergoing androgen Gabapentin (Neurontin, Gralise, others). This antiseizure medicine helps ease hot flashes. Side effects can include being drowsy, dizzy or tired and swelling in the Gabapentin, a GABA analogue, is useful for treating vasomotor symptoms in women, although the specific mechanism of action is not understood. Gabapentin was evaluated in a randomized, Results showed that Gabapentin at a dose of 300 mg 3 times daily reduced the frequency of hot flashes by approximately 50%. This study was a very small one which included only 214 men with prostate cancer enrolled from 45 centers.
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