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Analysis of 27 articles involving 2,016 patients showed significant reduction in pruritus incidence (OR, 0.30 [CI, 0.22–0.4]; I 2 =1%) and improvements in VAS (MD, 2.76 [CI, 0.95–4.57]; I 2 =98%) and 5-D scores (MD, 3.42 [CI, 2.10–4.75]; I 2 =92%) with pregabalin/gabapentin compared to controls. Gabapentin should be considered as a treatment option in patients with suspected neuropathic scalp pruritus; the dose of gabapentin is usually started low and titrated up to an effective dose . Adverse effects reported include dizziness, peripheral edema, and worsening of diabetes mellitus. promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic pruritus and neuropathic or neurogenic itch, in patients who fail conservative therapies. (J Am Acad Dermatol 2016;75:619-25.) Key words: gabapentin; itch; neurogenic itch; neuropathic itch; pregabalin; pruritus; uremic pruritus. C Gabapentin, an anticonvulsant, may control pruritus with neuropathic origin. The objectives of this study were to assess the efficacy of gabapentin in reducing pruritus scores of patients with uremic pruritus and evaluate its safety among dialysis patients. What is drug-induced pruritus? Pruritus is the medical name for itching.Drug-induced pruritus is an itch caused or triggered by medication. There are various itchy drug eruptions, but generally, the term ‘drug-induced pruritus’ implies that no primary rash is present — just scratch marks. Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for Multiple studies have demonstrated that gabapentin and pregabalin are effective for several forms of pruritus, in particular uremic pruritus and that of neural origin. Gabapentin and pregabalin are promising therapeutic options for pruritus refractory to conventional treatment. Conclusion: This systematic review discusses the effects of gabapentin as a treatment for various forms of pruritus. Overall gabapentin was an effective treatment for uremic, opioid induced, and The literature demonstrates gabapentin as an effective treatment modality in 11 articles for uremic pruritus, 9 articles for opioid-induced pruritus, and 2 articles for post-burn pruritus. Gabapentin impedes transmitting nociceptive sensations to brain, thus also suppressing pruritus. Gabapentin is safe and found to be effective in uremic pruritus, cancer/hematologic causes, opiod-induced itch, brachioradial pruritis, burns pruritus, and pruritus of unknown origin. This systematic review examines the current literature on Gabapentin’s therapeutic effects on all forms of pruritus and compares its efficacy based on etiology, demographics, and dosages. Gabapentin and pregabalin are safe and efficacious options to treat older adults with chronic pruritus. Prior to gabapentinoid initiation, the patient should be screened for: history of kidney disease; COPD or other lung disorders; current opioid medication use; history of falls, lightheadedness, or vertigo; history of mood disorders, including depression and suicidal ideation; history of Neuropathic pruritus: Gabapentin (Neurontin) 25, 26 Pregabalin (Lyrica) 25, 27: Drug-induced pruritus: a review. Acta Derm Venereol. 2009;89(3):236-244. Tandon P, Rowe BH, Vandermeer B, et al The use of gabapentin was responsible for a significant improvement in pruritus (p=0.0020). Besides itching and hyperchromic stain on the back, patients reported paresthesia and back pain. It was observed that the main factor in the worsening of the rash is heat. Approximately 15% of people with chronic pruritus have other causes including systemic diseases with secondary itch, such as uremic pruritus and cholestatic pruritus, medication-induced pruritus such as pruritus due to immunotherapy, and infectious etiologies such as tinea corporis and scabies. Several studies have shown gabapentin to be effective in in many chronic pruritus conditions.[57,58,59,60,61] Sheen et al. studied the role of gabapentin in the management of intrathecal morphine-induced pruritus. Evidence from 27 trials shows significant therapeutic value of the novel antiepileptic drugs pregabalin and gabapentin for pruritus, with a favorable safety profile. Gabapentin has also been shown to significantly improve pruritus secondary to interleukin-2 (IL-2), theoretically by blocking pruritic stimulation at afferent nerves . Regarding the use of pregabalin, case reports have described significant decreases in pruritus secondary to cetuximab and polycythemia vera, again expanding the utility of Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception. The aim of this double-blind, randomized, placebo-controlled trial was to study the effect of gabapentin on the The findings from original sources published to date to evaluate the use of gabapentin and pregabalin as antipruritic agents are explored. They are found to be promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic pruritus and neuropathic or neurogenic itch, in patients who fail conservative
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