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The main reasons for gabapentin misuse are as follows: getting high, alleviating opioid withdrawal symptoms and potentiating methadone effects. Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Losartan Interactions. There are 323 drugs known to interact with losartan, along with 7 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 32 are major, 275 are moderate, and 16 are minor. Compare Gabapentin vs Losartan head-to-head with other drugs for uses, ratings, cost, side effects and interactions. The study uses data from the FDA. It is based on gabapentin and losartan potassium (the active ingredients of Gabapentin and Losartan potassium, respectively), and Gabapentin and Losartan potassium (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. As a gamma-aminobutyric acid (GABA) analog, gabapentin essentially works by mirroring the effects of GABA calming excited neurons. Drug Interactions. Gabapentin may interact with certain medications or supplements. Because of drug interactions, using gabapentin with certain medicines is typically not recommended, but may be required in some cases. Specific Drugs: Gabapentin can interact with other prescription medications such as losartan, ethacrynic acid, caffeine, phenytoin, mefloquine, magnesium oxide, cimetidine, naproxen, sevelamer, and morphine. These interactions can lead to altered drug levels or an increased risk of side effects. If you are taking losartan you should avoid potassium-containing salt substitutes or over-the-counter potassium supplements without first talking to your doctor. This can cause high levels of potassium in your blood. The interaction between gabapentin and losartan is complex and multifaceted, involving significant pharmacokinetic changes that can enhance the anticonvulsant effects of gabapentin but also increase the risk of motor impairment and potential misuse. The interaction between losartan and gabapentin is not well-documented in scientific literature, and there is limited specific information available. However, based on their respective mechanisms of action and known interactions with other drugs, it is advisable to exercise caution when using these medications together. Research indicates that losartan significantly increases the plasma and brain concentrations of gabapentin. This interaction suggests a pharmacokinetic mechanism where losartan may affect the absorption, distribution, metabolism, or excretion of gabapentin, thereby enhancing its anticonvulsant activity . Losartan and Ethacrynic Acid: These are medications often used for blood pressure control, while the precise mechanism for interaction with gabapentin isn’t fully understood, combining these medications may affect how well the body processes each drug. This can lead to increased or decreased effect of either drug. Specific Medications: Gabapentin can also interact with specific medications including losartan (an antihypertensive), ethacrynic acid (a diuretic), phenytoin (an anticonvulsant), mefloquine (an antimalarial), magnesium oxide (an antacid), cimetidine (an antacid), naproxen (an NSAID), and sevelamer (a phosphate binder). These interactions can Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Common OTC pain relievers, like ibuprofen (Advil, Motrin), can interact with losartan. And potassium supplements can cause problems, too. Some losartan interactions can be avoided with safer alternatives. Others may need to be monitored closely. Let’s review a few possible losartan interactions you should know about. 1. Below are common gabapentin interactions and their associated effects: Losartan (angiotensin II receptor blocker): The combination of gabapentin and losartan may increase the risk of dizziness and drowsiness. Ethacrynic acid (diuretic): Gabapentin may decrease the effectiveness of ethacrynic acid. Caffeine: High doses of caffeine may increase However, it seems necessary to conduct more studies with larger sample sizes for confirming these effects. Gabapentin can interact with losartan, ethacrynic acid, caffeine, phenytoin, mefloquine, magnesium oxide, cimetidine, naproxen, sevelamer and morphine. Gabapentin use is contraindicated in patients with myasthenia gravis or myoclonus. Drug interactions are reported among people who take Gabapentin (gabapentin) and Losartan (losartan potassium). Common drug interactions include anxiety among females and chronic kidney disease among males. Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. The observed interaction between gabapentin and losartan could be pharmacokinetic in nature. Losartan increased plasma and total brain concentrations of gabapentin. In the chimney test, losartan (50mg/kg) administered with gabapentin (50mg/kg) caused motor impairment.
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