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Gabapentin is approved by the UD Food and Drug Administration for the treatment of seizures and PHN, 52 and is effective in the treatment of neuropathic forms of itch, such as brachioradial pruritus, prurigo nodularis, and notalgia paresthetica. 53 There are promising case reports regarding the use of gabapentin in scalp dysesthesia, 20 In the present study, the use of oral gabapentin 300 mg a day for the treatment of itching caused by NP showed to be efficient and led to a significant improvement in rates of itching intensity as assessed by the VAS. Other therapeutic considerations: Treatment of itch should potentially include some psychological and behavior modifications. Relaxation techniques, habit reversal training, and using competing physical sensation to block the itch are all potentially useful tricks that are clearly safe for patient to try. For example, in reports of DOPPS participants who had severe pruritus, 18 percent received no treatment for pruritus, and 17 percent did not even report their itch symptoms to health care staff . Over two-thirds of medical directors underestimated the prevalence of pruritus in their units [ 11,15 ]. Based on this theory, researchers hypothesized that gabapentin may relieve itching by blocking pruritic stimulation at afferent nerves, and conducted a retrospective review of patients with cancer treated with IL-2 (n = 17). 53 The study showed that gabapentin treatment (300-3600 mg/d) was associated with significantly improved pruritus using They are found to be promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic pruritus and neuropathic or neurogenic itch, in patients who fail conservative therapies. Keywords: gabapentin; itch; neurogenic itch; neuropathic itch; pregabalin; pruritus; uremic pruritus. There is currently no standardized algorithm for the treatment of chronic pruritus (CP), or itch lasting more than 6 weeks, in adults aged ≥ 65 years. The antiepileptic agents gabapentin and pregabalin, however, are gaining popularity in the dermatologic community for their efficacy in treating CP of neuropathic origin. Yet the lack of literature specifically looking at the safety and Gabapentin (Neurontin or Lyrica) Gabapentin was originally marketed as an anticonvulsant for individuals prone to seizures, but has been shown to be effective in treating both chronic pain and pruritus. Gabapentin can relieve itching sensations by blocking the effect of specific neurotransmitters and subduing neuronal hyperexcitability. 2 Gabapentin or pregabalin relieved itching in 85% of 71 consecutively treated CKD patients. Patients should be advised about side effects and the drug initiated at a low dose. Patients intolerant of gabapentin may tolerate pregabalin. All treatments should be performed considering an individual approach. This review article focuses on the understanding of the pathophysiology and the diagnostic and therapeutic management of scalp pruritus. 1. Introduction. Pruritus, also known as itch, is an unpleasant sensation that evokes a desire to scratch . It is a major and distressing the use of gabapentin and pregabalin as antipruritic agents are explored. They are found to be promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic pruritus and neuropathic or neurogenic itch, in patients who fail conservative therapies. (J Am Acad Dermatol 2016;75:619-25.) Gabapentin is successfully being used to treat skin conditions associated with pain or pruritus of neuropathic origin. What is gabapentin used for? Gabapentin is proving to be useful in reducing the symptoms of pain and unpleasant sensations caused by the following skin conditions: Pruritus (itch) In patients on haemodialysis Pruriceptive itch: This is an itch that starts in peripheral nerves in the skin. It can be caused by an allergic reaction, inflammation, skin dryness, or other skin damage. Psychogenic itch: This is a type of itch usually linked to mental illnesses, such as delirium. Seizure medication: Neurontin (gabapentin) is useful in treating itching associated with CKD and neurologic-related itching. Antidepressants: Selective serotonin reuptake inhibitors (SSRIs) are a type of antidepressant that can be used to treat different types of itching. The novel antiepileptic drugs pregabalin and gabapentin demonstrated significant therapeutic value in the treatment of pruritus, with a favorable safety profile. Compared to commonly used pruritus treatments such as antihistamines and antidepressants, these medications offered a promising alternative. Exciting treatments on the horizon include monoclonal antibodies as well as opioid modulators that serve as promising new treatment options for itch. Chronic itch is a common condition that affects the quality of life of many patients and can often be difficult to treat. Gabapentin is a well-established treatment option for itch with a reassuring safety profile that does not require continued lab monitoring. Generalized itching is a common cause of visits to the dermatologist and can be difficult to treat, leading to sleepless nights and inability to function. Gabapentin and pregabalin are promising therapeutic options for pruritus refractory to conventional treatment. Chronic pruritus is defined as itch lasting longer than 6 weeks. 1 It is associated with both primary dermatologic and systemic illness, and patients frequently experience psychological sequelae. 2. The treatment of chronic pruritus (CP), or itch lasting longer than 6 weeks, has long challenged the dermatologist, especially in older adults, defined as age ≥ 65 years. One class of drugs gaining popularity among dermatologists for its efficacy in treating and managing CP are the gabapentinoids. ralgia.6 Patients with other itchy conditions such as prurigo nod-ularis, aquagenic pruritus, and uremic pruritus have also reported relief of itch with capsaicin.11,12 Additionally, a more potent 8% capsaicin patch can provide prolonged relief in neuropathic itch when applied for an hour. However, as with any treatment for itch,
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