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Opioid Conversion Chart Equianalgesic dose refers to the amount of opioid equivalent to 10mg IV morphine. To convert between opioids determine the morphine equivalent of the first drug. Then convert the morphine equivalent dose to the new drug utilizing the table. * Do not administer IM unless no IV access due to pain with administration and Nil Equivalent dose Use liquid or disperse tablets in at least 30ml water for NG/PEG tubes. Disperse tablets in at least 30ml water for NJ/PEJ tubes. Contact neurology† for advice if no enteral feeding tube, an unlicensed IV clonazepam is available but not always appropriate. This section features links to a wide range of clinical resources on equivalent doses and conversions for opioids, benzodiazepines, antidepressants, antipsychotics, corticosteroids and more. Furthermore, you can also find equivalent dose charts for some of the popular classes of medicines here. Successful conversion between AEDs requires regular monitoring for patient-reported adverse effects and appropriately reactive adjustment of AED therapy to maximize patient quality of life. Keywords: epilepsy, antiepileptic drugs, conversion, monotherapy, polytherapy, quality of life. 1. Introduction Brivaracetam, Ethosuximide, Gabapentin, Lacosamide, Levetiracetam, Pregabalin, Tiagabine, Vigabatrin. If you take one of these medicines, there’s usually no need to stay on a particular version. The risk of different versions causing problems with seizures or side effects is extremely low. Children and adults: (IV) Total daily IV dose is equivalent to the total daily oral dose; IV dose should be divided every 6 hours; switch patients to oral as soon as clinically possible. IV has not been studied for >14 days. Die AMK übernimmt keinerlei Gewähr für die inhaltliche Vollständigkeit und Aktualität dieser Informationen. Haftungsansprüche gegen die AMK, welche sich auf Schäden infolge der Nutzung dieser Informationen beziehen, sind grundsätzlich ausgeschlossen. This calculator is for double-checking opiate conversion, and should NOT be used as the primary means for ordering. Pharmacists review the IV to PO patient list daily to identify potential candidates for IV to PO conversion based upon established criteria. All ADULT patients on any IV medications listed below are considered eligible for IV to PO conversion and should be assessed. Injection (IV) •Equivalent dose. 4 (all formulations) Use liquid for patients with NG/PEG tubes (licensed). • Give intravenously if NJ/PEJ or no enteral feeding tube. Clobazam . Tablets Liquid 1mg/ml Liquid 2mg/ml Nil •Equivalent dose Crush and disperse tablets in water for enteral tubes • Contact neurology for advice if no enteral tube. Nil Equivalent dose • Use liquid or disperse tablets in at least 30ml water forNG/PEG tubes. • Disperse tablets in at least 30ml water for NJ/PEJ tubes. • Contact neurology for advice if no enteral feeding tube, an unlicensed IV clonazepam is available but not always appropriate. IV to PO Conversion Regimen Recommendations Oral antimicrobials equally potent to the IV formulation Parenteral Therapy Oral Therapy Oral Bioavailability Ciprofloxacin 200 mg IV q12h Ciprofloxacin 400 mg IV q12h Ciprofloxacin 250 mg PO BID Ciprofloxacin 500 to 750 mg PO BID NOTE: space oral dose two hours before or six hours after Gabapentin, oxcarbazepine, and lamotrigine possess randomized controlled trial evidence for monotherapy treatment of partial-onset seizures and topiramate has evidence for monotherapy use in new onset epilepsy [3, 4]. Substitute with parenteral/intravenous (IV) formulation if available (non-formulary IV formulations denoted by asterisk*). 3. For AEDs without suitable IV substitutions, consider feeding tube placement. Switching is a potential problem when substituting a generic alternative for a branded AED and when prescribing generically because it is impossible to ensure the patient receives the same generic product each time. Child 6–11 years 10 mg/kg once daily (max. per dose 300 mg) on day 1, then 10 mg/kg twice daily (max. per dose 300 mg) on day 2, then 10 mg/kg 3 times a day (max. per dose 300 mg) on day 3; usual dose 25–35 mg/kg daily in 3 divided doses, some children may not tolerate daily increments; longer intervals (up to weekly) may be more appropriate, daily dose maximum to be given in 3 divided In an inpatient setting, rescue doses can be provided IV every 15-30 minutes. Oral rescue doses can be offered as needed over the normal dosing interval of the drug (typically every 4 hours). As stated above, because equianalgesic tables are inherently inaccurate, the availability of breakthrough doses is paramount. Benzodiazepine equivalent dosage converter. 4 mg/dose. Status epilepticus: 4 mg IV over 2 to 5 minutes. May repeat in 10-15 minutes. Usual maximum dose: 8 mg. Brivaracetam displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to the anticonvulsant effect. BRIVIACT is indicated as adjunctive therapy in the treatment of partial-onset seizures in patients 16 years of age and older with epilepsy. gabapentin, like Lyrica, does have abuse potential. This reinforces the importance of ensuring each patient taking gabapentin has an appropriate indication, dose and frequency to maximize benefit and avoid adverse events or misuse. Daily Dose of Gabapentin (mg/day) Daily Dose of Lyrica (mg/day) 0 – 300 50 301 – 450 75 451 – 600 100
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