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Dietary supplement (dosage in terms of magnesium oxide salt): Oral: 1 to 2 tablets (400 to 800 mg) daily; maximum: 2 tablets (800 mg)/24 hours. Dosing: Geriatric. Refer to adult dosing. Dosing: Pediatric. Note: 1,000 mg of magnesium oxide = 603.25 mg elemental magnesium = 49.64 mEq elemental magnesium. Review detailed drug interaction details between Gabapentin and Magnesium Oxide, including severity, interaction details, how to manage the interaction, and more. What is Magnesium? Magnesium has active ingredients of magnesium. It is often used in constipation. eHealthMe is studying from 121,014 Magnesium users for the drug's side effects, drug interactions, effectiveness and more. Check Magnesium in the real world. What is Gabapentin? Gabapentin has active ingredients of gabapentin. It is often used in Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. Gabapentin (200 mg) was orally administered alone, with 1 g magnesium oxide (MgO), or with 20 mg omeprazole to 13 healthy adult subjects. Oral bioavailability (BA) of gabapentin was estimated by 24-h urine collection. A Minor Drug Interaction exists between gabapentin and Mag-Oxide. View detailed information regarding this drug interaction. "Take gabapentin (Neurontin) at least 2 hours before, or 4 to 6 hours after taking magnesium supplements." - WebMD The window for taking it after magnesium is more debated (different sources have different answers) so personally I prefer to stick with the more conservative estimate and wait the longer period Compare Gabapentin vs Magnesium Oxide head-to-head with other drugs for uses, ratings, cost, side effects and interactions. When a magnesium-containing medication or supplement is taken with gabapentin, it can lower gabapentin’s effectiveness. It’s recommended to take gabapentin at least 2 hours after taking magnesium. Impact of Magnesium on Gabapentin Absorption. The concomitant administration of magnesium oxide with gabapentin has been shown to reduce the oral bioavailability of gabapentin. This interaction results in decreased plasma exposure and urinary excretion of gabapentin, likely due to reduced intestinal absorption. Gabapentin may decrease the absorption of magnesium oxide when taken at the same time, leading to reduced effectiveness of magnesium supplementation. This interaction may be more significant if the two medications are taken on an empty stomach. Any magnesium-containing supplement or medication, including magnesium oxide, magnesium citrate, and magnesium hydroxide (found in antacids), can interfere with gabapentin absorption. Even magnesium glycinate, often recommended for nerve pain, should be taken separately. Drug Interactions between gabapentin and Mag-Caps. This report displays the potential drug interactions for the following 2 drugs: gabapentin; Mag-Caps (magnesium oxide) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs If you decide to take magnesium and gabapentin together, be sure to follow the recommended dosage guidelines and monitor for any unusual symptoms or side effects. By taking these precautions, you can safely combine these two supplements for improved health and well-being. Common antibiotics that interact with magnesium include tetracyclines, such as Vibramycin (doxycycline) and Minocin (minocycline), as well as fluoroquinolones like Cipro (ciprofloxacin) and Levaquin (levofloxacin). Gabapentin absorption can be decreased by magnesium. Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Phenytoin (anticonvulsant): Gabapentin may increase the concentration of phenytoin, potentially leading to toxicity. Mefloquine (antimalarial): Mefloquine may increase the risk of seizures when combined with gabapentin. Magnesium oxide (mineral supplement): Taking magnesium oxide with gabapentin may reduce the absorption of gabapentin. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Magnesium can lower the absorption of bisphosphonates, some antibiotics and antiviral medications, and gabapentin (Neurontin) if they’re taken together. In some cases, separating the two products can help you avoid the interaction. But in other cases you may need to avoid the combination. Magnesium oxide Interactions. There are 229 drugs known to interact with magnesium oxide, along with 1 disease interaction.Of the total drug interactions, 9 are major, 128 are moderate, and 92 are minor.
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