Traditional treatment may include the medication gabapentin which is helpful with nerve pain. Some of the more forward-thinking neurologists are using neurological doses of IVIG and are having extraordinary effects. Keep in mind I also have POTS, MCAS, EDS, dysautonomia, and ME/CFS so it likely has to do with one of those. So, what it caused for me was that my veins puffed up to be very visibly "swollen" looking (kind of like an extreme version of when you have the tourniquet on your arm for a blood draw and your veins puff up a bit?) and I had very LPR has been linked to laryngopharyngeal vagal neuropathy (this is why it often occurs after a viral infection) and Amitryptiline is commonly used as a treatment for neuropathic pain and nerve damage. Amitryptiline is often prescribed along gabapentin, another drug for neuropathic pain, especially for cases resistant to PPIs/H2 blockers. The GABAa acting drugs like benzodiazepines, baclofen/GHB for GABAb, phenubut for GABAb and gabapentionods, pregabalin and gabapentin for Gabapentinoids seems to not only not release histamine but also help my stabilizing or calming down mast cells. A 2019 meta analysis of six outcome measures for gabapentin in AUD did find that adjunctive gabapentin (at TDD no lower than 900mg) reduced the number of heavy drinking days. It didn’t not impact craving nor amount of alcohol consumed on days that people did engage in drinking. Posted by u/Alarmed_Ability_8346 - 2 votes and 3 comments I keep getting this issue which is really really hard to explain but I will try, if anyone can relate and tell me if this sounds histamine related or have any idea what it might be I would be so grateful. Drs are stumped and just want to put me on gabapentin which I’m desperately trying to avoid. Gabapentin is really in a class of its own.. I'd call it a disbenzopiate haha. It has the warmth and optimism that you get from opiates with a nice anxiolytic effect on par with Xanax. That's great and all but the real reason I use Gabapentin is for the dissociative effects. It feels very much like MXE if you've ever done that. For nerve pain Gabapentin has helped me a lot. For muscle and body ache pain low-dose naltrexone (which they’ve found can go in higher doses than they previously thought) has also been helpful. I did terrible on gabapentin but being put on Primidone literally saved my life. I have Kounis Syndrome and the Primidone stopped the coronary arteries from closing down and giving me heart attacks. I had minor severity MCAS that started to become more severe about ten years ago. I came across some peer reviewed research articles about the potential for quercetin to reduce these symptoms. I looked further and found articles that found a synergistic effect by taking both quercetin and luteolin. Here is the list of medications that you and your doctor need to avoid using if you have MCAS and a list of potential alternatives that may support your health issue without further triggering MCAS (1, 2, 3). Don’t know if this is your case but if your dysautonomia causes tachycardia, be very careful with beta blockers! They can cause mast cell activation and can make MCAS symptoms worse. A significant portion of people with POTS also have MCAS so this information should be spread. Is OP asking about gabapentin, or Gamma-Aminobutyric Acid (GABA)? 15K subscribers in the MCAS community. A science-focused sub for Mast Cell Activation Disorders. Please note: The content on this subreddit is not Have you tried allergy medication. This sounds dumb but I have MCAS along with everything else and my specialist said that there would be 3 types of pain to try different stuff for. The sharp joint pains which need regular pain medication. Me, My Stomach, and MCAS; MCAS Testing! Further Reading: Treatments for Mast Cell Diseases; Medications for Mast Cell Diseases; Approach to MCAS Diagnosis and Treatment (LB Weinstock) RULES. 1. Remember the human. Behind the usernames on this sub are people - many of whom are suffering with distressing symptoms and looking for answers. It clears ammonia from the brain and GABA seems to increase ammonia or things that increase GABA or work on its receptors increase ammonia. Things that increase GABA are fasting and sleeping. Things that work on GABA receptors are benzos, phenibut, baclofen, gabapentin and more. 90. What causes pain in mast cell disease? Most mast cell patients experience some kind of pain. Because mast cells are involved in pain sensation and inflammation, mast cell patients are at risk of pain by different mechanisms throughout their body. Mast cells are involved in nerve pain. Mast cells often live very close to Read More »The MastAttack 107: The Layperson’s Guide to I have taking Gabapentin for years, so I knew that we have GABA receptors in the brain and nervous system that affect muscle tension, anxiety, OCD behaviors, pain, seizures, etc. The supplement just adds more actual GABA to the mix, as where neurotin specifically antagonizes a certain GABA receptor. GABA is an amino acid and neurotransmitter, Gabapentin is a drug; perhaps that's what you are thinking of. GABA has been shown to be non-addictive, and can actually reduce the addictiveness of other drugs by reducing dopanergic response. There's not much evidence to suggest GABA actually crosses the blood brain barrier either.
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