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Gabapentin is the most commonly prescribed medication for the treatment of chronic musculoskeletal pain in cats. Despite this common and chronic usage, clinically relevant pharmacokinetic data is lacking. To evaluate the pharmacokinetics of clinically relevant dosing regimens of gabapentin in cats. Eight research-purpose mixed-breed cats. To date, only 1 study has investigated the pharmacokinetics of transdermal drug delivery of gabapentin in cats. 19 Although that study suggested poor transdermal absorption of gabapentin, minimal or no data was reported because many results were below the limit of detection and the duration of the transdermal application was unclear. 19 Gabapentin is the most commonly prescribed medication for the treatment of chronic musculoskeletal pain in cats. Despite this common and chronic usage, clinically relevant pharmacokinetic data is lacking. To evaluate the pharmacokinetics of clinically relevant dosing regimens of gabapentin in cats. Eight research‐purpose mixed‐breed cats. The same five healthy cats plus 25 cats with stable International Renal Interest Society stage 2 (n = 14) and 3 (n = 11) CKD were enrolled in a limited sampling study. Cats in both groups received a single 10 mg/kg dose of gabapentin, and serum gabapentin concentrations and compliance scores were obtained 3 and 8 h post-administration. OBJECTIVE: To determine the pharmacokinetics of gabapentin in cats after IV and oral administration. ANIMALS: 6 healthy female adult domestic shorthair cats. PROCEDURES: Gabapentin was administered IV (4 mg/kg) or orally (10 mg/kg) in a crossover randomized design. Although gabapentin has been demonstrated to be moderately effective as an add-on anticonvulsant medication in dogs , the pharmacokinetics of oral gabapentin in cats predict that it would require 3 mg/kg q6h dosing to reach and sustain targeted anticonvulsant plasma concentrations in humans . On the other hand, our study suggests that 4.2. Pharmacokinetics in Cats. Nowadays, gabapentin PKs in cats are still poorly investigated, and the literature reported quite different results, even though similar doses were evaluated. The first study by Siao et al. (2010) aimed to determine the PKs of gabapentin in cats receiving 4 mg/kg IV or 10 mg/kg orally . Although gabapentin has been demonstrated to be moderately effective as an add-on anticonvulsant medication in dogs , the pharmacokinetics of oral gabapentin in cats predict that it would require 3 mg/kg q6h dosing to reach and sustain targeted anticonvulsant plasma concentrations in humans . On the other hand, our study suggests that This review aimed to clarify gabapentin use and pharmacokinetic aspects to promote conscious use in dogs, cats, and horses. In dogs, gabapentin was beneficial in the treatment of epilepsy, as well as chronic, neuropathic, and post-operative pain, as well as anxiety. Gabapentin plasma concentrations after administration as an IV bolus (5 mg/kg) in 8 cats (open diamonds) with modeled timeconcentration curve (using geometric mean of derived parameters; solid Objectives: To evaluate the pharmacokinetics of clinically relevant dosing regimens of gabapen-tin in cats. Animals: Eight research-purpose mixed-breed cats. Methods: Cats were enrolled in a Objective: To determine the pharmacokinetics of gabapentin in cats after IV and oral administration. Animals: 6 healthy female adult domestic shorthair cats. Procedures: Gabapentin was administered IV (4 mg/kg) or orally (10 mg/kg) in a crossover randomized design. Blood samples were obtained immediately before gabapentin administration and at This review aimed to clarify gabapentin use and pharmacokinetic aspects to promote conscious use in dogs, cats, and horses. In dogs, gabapentin was beneficial in the treatment of epilepsy, as well Gabapentin is an anticonvulsant drug, which presents an established clinical efficacy in human patients for the management of refractory partial seizures, secondarily generalized tonic-clonic seizures, and for the control of chronic neuropathic pain. Gabapentin was synthesized as a structural analogue of the inhibitory neurotransmitter GABA, with GABA-mimetic effects, able to cross the blood The pharmacokinetics of single oral (10 mg/kg) and intravenous (IV; 4 mg/kg) doses of gabapentin in 6 adult spayed female cats has been described, 13 but no other data are available on the pharmacokinetics of gabapentin in the cat. Due of this paucity of data relevant to the clinical use of the drug, the pharmacokinetics of gabapentin The pharmacokinetics of single oral (10 mg/kg) and intravenous (IV; 4 mg/kg) doses of gabapentin in 6 adult spayed female cats has been described, 13 but no other data are available on the pharmacokinetics of gabapentin in the cat. Due of this paucity of data relevant to the clinical use of the drug, the pharmacokinetics of gabapentin Objectives: To evaluate the pharmacokinetics of clinically relevant dosing regimens of gabapentin in cats. Animals: Eight research-purpose mixed-breed cats. Methods: Cats were enrolled in a serial order, non-randomized pharmacokinetic study. Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24 and 36 h via a jugular catheter. Serum gabapentin concentrations were measured using liquid chromatography coupled to tandem mass spectrometry. Objective—To determine the pharmacokinetics of gabapentin in cats after IV and oral administration. Animals —6 healthy female adult domestic shorthair cats. Procedures —Gabapentin was administered IV (4 mg/kg) or orally (10 mg/kg) in a crossover randomized design. The pharmacokinetics for dogs 12 and cats 13 indicate that gabapentin administration every 6 to 8 hours, rather than every 12 hours as commonly used, may be needed to provide serum concentrations of gabapentin that are adequate for analgesia. Thus, for each patient, both the dose and the administration frequency may need to be explored, for
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