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Specific Medications: Gabapentin can also interact with specific medications including losartan (an antihypertensive), ethacrynic acid (a diuretic), phenytoin (an anticonvulsant), mefloquine (an antimalarial), magnesium oxide (an antacid), cimetidine (an antacid), naproxen (an NSAID), and sevelamer (a phosphate binder). These interactions can Dilantin Interactions. There are 848 drugs known to interact with Dilantin (phenytoin), along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 240 are major, 563 are moderate, and 45 are minor. Phenytoin and/or gabapentin were strongly suspected as causing his hypothyroidism. The patient was treated with replacement therapy (levothyroxine 25 μg/day). His symptoms markedly and promptly improved alongside continued antiepileptic therapy. In addition, gabapentin can interact with antiepileptic drugs (phenytoin, mefloquine), 86, 87 antacids (magnesium oxide, cimetidine), 89,90 nonselective nonsteroidal anti-inflammatory drugs Phenytoin. In a single (400 mg) and multiple dose (400 mg three times a day) study of gabapentin in epileptic patients (N = 8) maintained on phenytoin monotherapy for at least 2 months, gabapentin had no effect on the steady-state trough plasma concentrations of phenytoin and phenytoin had no effect on gabapentin pharmacokinetics. According to the criteria of causation it can be considered a possible adverse reaction caused by phenytoin related to incorporation of gabapentin. The mechanisms of this possible drug interaction are discussed, with emphasis on cytochrome P450 metabolism. CONCLUSION. Use the interactions A to Z to look up a drug and see which other drugs it interacts with and the severity of these interactions. Before taking phenytoin, tell your doctor if you also use gabapentin. This combination may increase the phenytoin levels in your body. This combination may cause drowsiness, visual problems, seizures, changes in behavior, nausea, or poor muscle coordination. Compare Gabapentin vs Phenytoin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. According to the criteria of causation it can be considered a possible adverse reaction caused by phenytoin related to incorporation of gabapentin. The mechanisms of this possible drug interaction are discussed, with emphasis on cytochrome P450 metabolism. Drug interactions are reported among people who take Gabapentin (gabapentin) and Phenytoin (phenytoin). Common drug interactions include depressed mood among females and drug ineffective among males. The phase IV clinical study analyzes what interactions people have when they take Gabapentin and Phenytoin, and groups them by gender, age and more. Phenytoin Interactions. There are 848 drugs known to interact with phenytoin, along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 241 are major, 562 are moderate, and 45 are minor. Gabapentin has shown no effect on phenytoin (Dilantin), carbamazepine (Tegretol), valproic acid (Depakene) and phenobarbital levels . No clinically important interaction has been demonstrated with Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. Dilantin (phenytoin) is also an anticonvulsant medication used to treat seizures. Both gabapentin and dilantin can be effective in treating seizures, but they can also interact with each other. Mechanism of Interaction. Gabapentin and dilantin are both metabolized in the liver by the enzyme cytochrome P450 3A4 (CYP3A4). idism following AEDs is rarely reported in the literature. Patient concerns: A 75-year-old man experienced neurologic symptoms including memory impairment, ataxic gait, sensory polyneuropathy and myopathy, lethargy, and edema of the face and lower extremities. He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before. Diagnoses: The However, it seems necessary to conduct more studies with larger sample sizes for confirming these effects. Gabapentin can interact with losartan, ethacrynic acid, caffeine, phenytoin, mefloquine, magnesium oxide, cimetidine, naproxen, sevelamer and morphine. Gabapentin use is contraindicated in patients with myasthenia gravis or myoclonus. Drug interactions are reported among people who take Gabapentin (gabapentin) and Dilantin (phenytoin sodium). Common drug interactions include injury among females and convulsion among males. The phase IV clinical study analyzes what interactions people have when they take Gabapentin and Dilantin, and groups them by gender, age and more. Phenytoin Sodium Interactions. There are 848 drugs known to interact with Phenytoin Sodium (phenytoin), along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 240 are major, 563 are moderate, and 45 are minor. A Moderate Drug Interaction exists between gabapentin and Phenytoin Sodium. View detailed information regarding this drug interaction.
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