We reviewed records of 30 consecutive patients who had been diagnosed with PTSD according to structured interviews and had received gabapentin as an adjunctive medication. For each patient, the Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use disorder. There is sufficient evidence to consider gabapentin as a third-line treatment for social anxiety disorder and severe panic disorder. From a bigger picture perspective, if nightmares are a symptom of PTSD, getting effective trauma treatment, such as EMDR (eye movement desensitization and reprocessing), should help with nightmares. In the meantime, though, getting enough sleep is an important part of the healing process, so that may warrant adding nightmare-specific interventions. This retrospective study suggests that gabapentin may improve in particular sleep difficulties and also other symptoms associated with chronic PTSD. Prospective, controlled studies are needed to further investigate the effects of gabapentin on insomnia, nightmares, and other core PTSD symptoms. The available data suggest that gabapentin is a potentially effective adjuvant agent in the treatment of PTSD. In a retrospective study (n = 30), 62 the majority of PTSD patients (77%) treated with adjunctive gabapentin (300–3,600 mg/d) demonstrated moderate improvement in sleep duration and a decrease in nightmares. Objective: To report the effects of gabapentin in a patient with concurrent depression and posttraumatic stress disorder (PTSD) and review the use of antiepileptic drugs (AEDs) in PTSD. Case summary: A 37-year-old Latin American woman was being treated for major depression and PTSD. In conclusion, gabapentin’s journey from an anticonvulsant to a tool in mental health treatment is a testament to the complex and interconnected nature of our brains. While it’s not a panacea, it offers hope and potential relief for many individuals battling anxiety, mood disorders, and other mental health challenges. Post-traumatic stress disorder (PTSD) is a disruptive, chronic, and relatively common disorder that is often difficult to treat. Many patients with PTSD are unresponsive, have only moderate or marginal responses, or have troubling side effects to first-line serotonin reuptake inhibitor treatment. St Gabapentin’s potential in addressing PTSD symptoms lies in its ability to modulate neurotransmitter activity and influence these dysregulated brain systems. By affecting calcium channels, gabapentin may help reduce the excessive neuronal excitability often seen in PTSD. GBP may have some therapeutic potential in the treatment of opioid addiction and cannabis dependence, but there is limited evidence to support its use. No significant benefit of GBP has been conclusively observed in the treatment of OCD, PTSD, depression, or cocaine and amphetamine abuse. OBJECTIVE: This article describes current approaches to the pharmacologic treatment of posttraumatic stress disorder (PTSD) and reviews the classes of pharmacologic agents used in the treatment of PTSD. Pharmacotherapy for PTSD that is comorbid with other psychiatric disorders is highlighted. METHODS: The primary-source literature was reviewed by using a MEDLINE search. Secondary-source review In addition to propranolol and hydrocortisone, observational studies have associated early morphine use with reduced rates of PTSD 21 and other drugs, including SSRIs 22, gabapentin 23, α-omega Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. Ann Clin Psychiatry. 2001;13(3):141-146. 29. Jetly R, Heber A, Fraser G, Boisvert D. The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: a preliminary randomized, double-blind, placebo-controlled cross-over design study. We reviewed records of 30 consecutive patients who had been diagnosed with PTSD according to structured interviews and had received gabapentin as an adjunctive medication. For each patient, the target symptoms that led to the initiation of gabapentin treatment were identified. The available data suggest that gabapentin is a potentially effective adjuvant agent in the treatment of PTSD. In a retrospective study (n = 30), 62 the majority of PTSD patients (77%) treated with adjunctive gabapentin (300–3,600 mg/d) demonstrated moderate improvement in sleep duration and a decrease in nightmares. Systematic reviews of gabapentin treatment in psychiatric and/or substance use disorders showed preoperative anxiety; post-traumatic stress disorder, PTSD; obsessive-compulsive disorder, OCD US Pharm. 2006;11:31-38. Posttraumatic stress disorder (PTSD) is a severe and chronic condition, with a lifetime prevalence of 1.3% to 7.8% in the general population. 1 The three main characteristics and diagnostic criteria for PTSD are symptoms of reexperiencing, numbing and avoidance, and hyperarousal. 2 PTSD occurs after an individual experiences, witnesses, or is confronted with a A case is presented in which a patient diagnosed with posttraumatic stress disorder (PTSD) who had been taking multiple medications with little clinical response was placed on gabapentin treatment with beneficial results. the area of PTSD psychopharmacology trials. • Foundational studies are required to inform the optimal prescription of commonly prescribed medications for the treatment of PTSD. • The development of a psychopharmacology clinical trials workforce and infrastructure for PTSD would advance the goal of increasing clinical trials in this area. Mood stabilizers aren’t typically a first-line treatment for PTSD because they can cause severe side effects and lead to other medical problems such as kidney and liver function issues.
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