Fluid Retention. One common reason for swelling is fluid retention. Gabapentin can cause changes in kidney function or fluid balance in the body. When the body retains excess fluid, it can lead to noticeable swelling in areas like the legs, ankles, or hands. Allergic Reactions. In rare cases, swelling may result from an allergic reaction to Other gabapentin side effects include edema (fluid buildup), weight gain, and eye problems, but these aren’t as common. Rare but serious gabapentin side effects include mood changes in children. It can also cause suicidal thoughts or behaviors in children and adults. Seven days after the administration of the gabapentin, the patient complained from pain and edema and scaling and hyperesthesia in his lower extremities and pitting edema, pain and tenderness. The range of motion of the extremities was been increased. According to the patient statement the gabapentin brand has been changed. For the next 7 days, the patient continued to experience bilateral, painful, 3 to 4+ pitting edema despite compression socks and fluid restriction. Yes, gabapentin may cause fluid retention and induce edema in arms and legs. Experts believe that this side effect can also be the reason for weight gain by increasing your water weight. It can also make the body look bulky. Background Gabapentin and pregabalin are commonly prescribed medications to treat pain in patients with diabetic neuropathy. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. This study aims to Gabapentin is a medication used to treat seizures, restless legs syndrome, and nerve pain from shingles. Some people taking it report fluid retention and swelling in their extremities. Swelling may be more likely if you’re older, or if you’re taking a higher gabapentin dosage. I've read a lot of the questions and answers about the weight gain caused from Gabapentin and some said it was a water or bloating reason, and I was wondering if it is a water weight gain, can your physician prescribe a water pill like Lasix, and would that help with the weight gain. Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect of another drug. All cases of peripheral edema or heart failure [Medical Dictionary for Regulatory Activities (MedDRA) Hight-Level Term ‘total volume fluid increased’ or High-Level Group Term ‘heart failures’] involving gabapentin or pregabalin and recorded between January 1, 1994 and April 30, 2020 were selected. Gabapentin does help with the pain but, I don’t like the swelling. It also makes me drowsy but I sleep good. The drug has pros and cons about it. I have been on it for about 8.5 years with no fluid retention or other side effects. Thanks for your response but Im not 100% convinced that is true. This occurs in around 8% of patients taking gabapentin. 1. Gabapentin may cause weight gain by increasing your appetite, causing fluid retention, and inhibiting physical activity by causing fatigue. Because gabapentin is an anticonvulsant, it prevents seizures and nerve pain by reducing nerve activity in the central nervous system. Increased Appetite: Gabapentin can sometimes stimulate your appetite, making you feel hungrier and more inclined to eat more than you usually would. Fluid Retention: The medication can lead to fluid retention, causing swelling, particularly in the extremities like hands, legs, and feet. This water weight contributes to overall weight gain. Fluid retention is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Furosemide, and have Depression. The cause of weight gain with gabapentin is likely due to increased appetite. You may be hungry more often. In some cases, weight gain may be due to fluid retention, another side effect of gabapentin. Another possible cause is not getting enough exercise if gabapentin is causing fatigue. Some ways to avoid weight gain include: Fluid retention in Gabapentin; How the study uses the data? The study is based on gabapentin (the active ingredients of Gabapentin). Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study. Fluid retention, or edema, can occur when gabapentin affects vascular permeability or alters kidney function. Edema refers to swelling caused by excess fluid accumulation in tissues. It can occur in various parts of the body but is most commonly seen in the legs, ankles, and feet. Gabapentin can cause fluid buildup in the legs (edema), which can lead to temporary weight gain. You can also gain weight without fluid buildup, though it’s not common. You may be able to avoid weight gain from gabapentin by adjusting your diet and exercising regularly. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. Background. Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of indications both Food and Drug Administration approved and off-label. 1-3 It is approved by the Food and Drug Administration to treat postherpetic neuralgia and epilepsy 4 with common off-label indications including fibromyalgia, anxiety, mood disorders, and
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