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Gabapentin has an average rating of 8.7 out of 10 from a total of 111 reviews for the off-label treatment of Hot Flashes. 87% of reviewers reported a positive experience, while 8% reported a negative experience. Randomised controlled trials (RCTs) that compared the efficacy and tolerability of gabapentin with placebo for treating hot flashes (or hot flushes) in women with either natural or tamoxifen-induced menopause were eligible for inclusion. Gabapentinoids (gabapentin and pregabalin) Multiple randomized controlled trials have shown that when compared with placebo, gabapentin is effective at reducing hot flash frequency by 54% and hot flash composite score (combined hot flash frequency and severity score) by 31% to 51%. Step-wise approach to management of menopausal hot flashes. M ANAGEMENT. The management of HFs is guided by their frequency and severity. The severity of HFs can be graded as (a) mild (no interference with usual daily activities), (b) moderate (interfere with usual daily activities to some extent), and (c) severe (when usual daily activities cannot be performed).[] Randomised placebo-controlled trials have shown that venlafaxine, 16 fluoxetine, 17 and paroxetine 18 are effective in control of hot flashes. Gabapentin is a GABA analogue used in the treatment of epilepsy, neurogenic pain, restless-leg syndrome, essential tremor, bipolar disorder, and migraine prophylaxis; it was first reported for its Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses. There are several good quality clinical trials that address gabapentin for hot flashes and it has even been the subject of a recent meta-analysis. In studies, gabapentin reduced hot flashes from 45%-71% depending on the dose. Talk to your healthcare professional about the pros and cons of treatments for hot flashes. If hot flashes don't bother you much, you likely don't need treatment. For most people, hot flashes go away slowly, even without treatment. But it can take several years for them to stop. Gabapentin appears to be effective for reducing hot flashes, although potentially not as effective as estrogen therapy. A 2019 review and meta-analysis in the American Journal of Obstetrics There are many treatments for hot flashes, but gabapentin may be a better choice for some women. Studies have found gabapentin to be effective in relieving severe hot flashes after just 12 weeks of treatment. Gabapentin presents a promising option for managing hot flashes, particularly for those who haven’t found relief through other treatments. By understanding its benefits, potential side effects, and proper administration, you can make informed decisions about its use. Hot flashes happen in about 80% of menopausal women and on average, last for more than seven years. Though some women continue to experience them longer than 10 years. Dr. Kling says that treating hot flashes and having another option to help women during these years creates a ripple effect. 45 percent decrease in hot flashes with gabapentin versus 29 percent with placebo (P = .02, NNT = 6) Somnolence; dizziness: a systematic review of its clinical efficacy. Eur J Clin Pharmacol. The following search terms were used: "menopause," "hot flushes," "vasomotor symptoms," "gabapentin," and "non-hormonal therapy." Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and dropout rate. Examining individual trials, the two trials that evaluated 900 mg/d of gabapentin reported that hot flashes were decreased by 45% to 50% (Fig 1E). 15,16 In the individual patient trial that studied 2,400 mg/d, hot flashes were reported to be reduced by approximately 80% (Fig 1E). 17 In this last trial, however, there was a much more substantial earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and
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