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The results suggest that gabapentin may be of benefit to bipolar patients who only partially respond to other mood stabilizers. A favorable side-effect profile and rapid action make this drug an attractive choice as an adjunctive therapy. Gabapentin for Bipolar Disorder User Reviews Brand names: Neurontin, Gralise, Gabarone, Fanatrex Gabapentin has an average rating of 8.5 out of 10 from a total of 138 reviews for the off-label treatment of Bipolar Disorder. Gabapentin (Neurontin) is FDA approved to treat seizure disorder and nerve pain from shingles. But it’s also used off-label to treat many other conditions, including anxiety, nerve pain from diabetes, and hot flashes. Gabapentin may be effective for anxiety, but it’s usually not a first-choice medication for this use. Patients frequently express an interest in using gabapentin rather than standard mood-stabilizing agents (like lithium carbonate, divalproex sodium, or carbamazepine) due to its limited side effect profile. Thus, clinical interest regarding its use in mood disorders has grown. American Psychological Association: Gabapentin has been “largely discredited as a mood stabilizer for bipolar disorder.” Depression and Bipolar Support Alliance: Gabapentin “was used frequently for treatment of bipolar disorder, but controlled studies found it was no more effective than a placebo.” Several studies have looked at the mood-altering effects of gabapentin, and the results are, well, mixed. Some research suggests that gabapentin might have mood-stabilizing properties, potentially helping with conditions like bipolar disorder. It’s like the medication is acting as an emotional shock absorber, smoothing out the highs and lows. This article reviews evidence-based psychiatric uses of gabapentin, along with associated risks. An extensive literature review was conducted, primarily of articles searchable in PubMed, relating to psychiatric uses, safety, and adverse effects of Thus, we have carried out a systematic review and meta-analysis of the efficacy, acceptability and tolerability of gabapentin and pregabalin in the treatment of BD, anxiety and insomnia. For 1 year, 13 patients received adjunctive gabapentin with standard mood stabilizers and 12 patients received adjunctive placebo. On the basis of the CGI-BP, gabapentin-treated patients showed significant improvement from baseline to month 12. Gabapentin User Reviews & Ratings Brand names: Neurontin, Gralise, Gabarone, Fanatrex. Gabapentin has an average rating of 7.2 out of 10 from a total of 2,569 reviews on Drugs.com. 64% of reviewers reported a positive experience, while 21% reported a negative experience. A large number of peer-reviewed but noncomparative studies and reviews 23–25,27–31,33–37,39,40 also support gabapentin’s role either as monotherapy after first-line treatment failure or as adjunctive therapy to mood stabilizers, antidepressants, or neuroleptics. Mood stabilizers: HAM-D, BMR: Reduced Hamilton Depression (p < 0.05) and Beck Mania Ratings (p < 0.01) were evident in the first week of treatment and were sustained. GBP may, therefore, be beneficial for bipolar patients who only respond partially to other mood stabilizers. Stein et al./2007/RCT : Posttraumatic stress disorder: 48: 14 days This paper reviews the experience to date with these agents in the treatment of psychiatric conditions. Gabapentin demonstrates promise for the treatment of panic and generalized anxiety, while both gabapentin and lamotrigine appear useful as mood stabilizers in the treatment of bipolar disorder. Adjunctive therapy of gabapentin to stable doses of mood stabilizers or atypical antipsychotics, initiated at 300 mg at bedtime and increased by 300 mg every four nights until symptom relief or adverse effects were noted. Final GBP dose was clinically determined. Maximum dose 3600 mg per day in divided doses (range 600 mg to 3300 mg). If used as a mood stabilizer or anti-depressant, the dose is usually between 900 and 2,000 mg a day. But, it may also be increased for better results. Some people see improvement in their OBJECTIVE: Polypharmacy is common in the treatment of refractory bipolar disorder. The purpose of this article is to review the safety and efficacy of mood stabilizers in combinations. METHOD: A manual and computer (MEDLINE) search was performed for combinations of the most commonly used mood-stabilizing agents. RESULTS: The authors review safety and efficacy data on the more frequently Gabapentin may cause side effects such as dizziness, drowsiness, and dizziness. It is important to follow the prescribed dosage and seek medical attention if experiencing serious side effects or changes in mood or behavior. Gabapentin is prescribed by healthcare professionals and should only be taken under medical supervision. I take Gabapentin (1200 mg/4x day). Due to problems with nearly all other known mood stablizers, it's the only med I can currently take. Research indicates that Gabapentin is good at lowering the highs, but though it can pull one out of deep depression, it's not as affective at pulling ppl out of low-grade depression on its own. Gabapentin is off label for bipolar disorder but from what my doctors have said its not really a good mood stablizer. I used it in the past for anxiety and it worked for that. I mean id say give it a shot and if i stablizes your mood thats great. Its a safer drug than being on heavier stuff like antipsychotics Outpatient prescription of gabapentin for FDA-approved indications (i.e., partial-onset seizures and postherpetic neuralgia) was less than 1%, and depression and anxiety disorders were the most frequent psychiatric diagnoses among off-label users.
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