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Gabapentin sexual side effects include decreased sex drive, trouble reaching orgasm, and erectile dysfunction. Sexual problems can occur for many reasons. So if you’re having sexual changes while taking gabapentin, it may not be the medication. ache and prevention of migraine. Few cases were reported with sexual dysfunctions (SDs) as adverse effects of PGB and gabapentin, and the majority were dose related (≥900 mg/d for gabapentin). This study aimed to determine the frequency and types of SDs induced by PGB and the temporal relation to its use. Methods We presented case series of patients (n = 75) treated with PGB for different By Pat Anson, PNN Editor Over the years the nerve drug gabapentin (Neurontin) has been used to treat a cornucopia of chronic pain conditions, from fibromyalgia and diabetic neuropathy to hot flashes and shingles. Gabapentin is so widely prescribed that a Pfizer executive once called the drug “th Low-dose gabapentin may result in marked sexual dysfunction, including loss of libido, erectile dysfunction, ejaculatory dysfunction, and anorgasmia. Such sexual dysfunction may lead to medication noncompliance. Patients often do not volunteer information regarding sexual dysfunction, and therefore, targeted questions are necessary. Frequency Of Sexual Side Effects. Gabapentin’s sexual side effects are not as well studied as other effects of the drug. An estimated 1-5% of gabapentin users may have some sexual side effects and the true frequency may be limited due to underreporting. Reduced libido and erectile dysfunction (ED) are the most commonly reported issues. Studies on gabapentin’s sexual side effects have shown that sexual dysfunction caused by this medication in both men and women was resolved when their doses were reduced or when their medications were changed. literature on gabapentin-induced sexual dysfunction [10,13,17,21–24]. This case describes the stepwise development of sexual dysfunction as gabapentin was titrated at low daily doses. 2. Method Case analysis with PUBMED literature review was employed. 3. Case report A 34-year-old man presented with major depression, social This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation, anorgasmia, and impotence) at a total daily dose of only 300 mg. Gabapentin could cause erectile dysfunction, sexual desire changes and ejaculatory dysfunction. There’s evidence that gabapentin may affect a man’s ability to reach orgasm (either by causing premature ejaculation or delayed ejaculation), especially if he’s older. The first step if you're experiencing erectile dysfunction is to talk with your gabapentin-prescribing doctor about changing treatment or whether your dose can be reduced. If this is not possible, it may make sense to discuss using a PDE5 inhibitor to help with erection issues. A man suffering from erectile dysfunction. One important concern regarding Gabapentin-induced sexual dysfunction is whether this side effect is reversible or permanent. Fortunately, there are currently no scientific studies indicating that Gabapentin-induced sexual dysfunction is permanent. Mirtazapine may avoid the sexual dysfunction present with other SSRIs and trazadone is known to cause priapism, which has been postulated to be due to 5-HT 1C upregulation. 1 In a study by Rosen et al, up to 58% of patients on SSRIs reported sexual dysfunction. 22. Gabapentin, pregabalin, and oxycodone also had a high number of reported ED In men, Gabapentin is associated with sexual dysfunction. Men who use the medication have a high incidence of anorgasmia or difficulty in achieving an orgasm. Gabapentin-induced sexual dysfunction is common in older men. When to See a Doctor. When your doctor prescribes Gabapentin they should advise you about the side effects. Sexual dysfunction is a key adverse effect leading to medication noncompliance. Psychotropic drugs associated with sexual dysfunction include antiepileptic drugs, antidepressants, and antipsychotics. Gabapentin, frequently used off-label to treat psychiatric and pain disorders, has previously been reported to cause sexual dysfunction at a minimum total daily dose of 900mg. This report Low-dose gabapentin may result in marked sexual dysfunction, including loss of libido, erectile dysfunction, ejaculatory dysfunction, and anorgasmia. Such sexual dysfunction may lead to medication noncompliance. If you have begun to experience erectile dysfunction after taking gabapentin, you are not alone. ED caused by gabapentin is a potential side effect. Additionally, research shows several medications used for treating epilepsy can cause sexual dysfunction in both men and women.
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