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Sexual side effects from gabapentin aren’t common. But they’re possible and include decreased sex drive (libido) and trouble getting or keeping erections (erectile dysfunction). If you’re taking gabapentin and experiencing sexual problems, talk with your prescriber. Erectile dysfunction (trouble getting or keeping an erection) is a possible gabapentin side effect in men. But it’s unclear how likely gabapentin is to cause sexual side effects like erectile dysfunction. Human sexual response involves a complex interplay between many neurotransmitters including dopamine, serotonin, norepinephrine, acetylcholine, γ-aminobutyric acid, oxytocin, opioids, and nitric oxide and neuromodulators. In particular, whereas dopamine seems to promote sexual desire and arousal, serotonin has an inhibitory effect on sexuality. There are a number of prescription and over-the-counter drugs that may cause erectile dysfunction. While these drugs may treat a disease or condition, they can also affect a man's hormones, It also has off-label uses for the treatment of generalized anxiety disorders, fibromyalgia, and tension headache and prevention of migraine. Few cases were reported with sexual dysfunctions (SDs) as adverse effects of PGB and gabapentin, and the majority were dose related (≥900 mg/d for gabapentin). If you have begun to experience erectile dysfunction after taking gabapentin, you are not alone. ED caused by gabapentin is a potential side effect. Additionally, research shows several medications used for treating epilepsy can cause sexual dysfunction in both men and women. Gabapentin, a medication commonly used for managing seizures and pain, can indeed contribute to Erectile Dysfunction as a potential side effect. While not everyone experiences this issue, research suggests a link between Gabapentin and sexual dysfunction, including ED, decreased libido, and other related issues. Erectile dysfunction is a common side effect of gabapentin, and the conditions that gabapentin treats are typically much more serious than dealing with sexual dysfunctions. It’s important to keep taking the medication if your doctor suggests it. Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Key Words: Erectile Dysfunction, Medications, Side Effects, Sexual Function INTRODUCTION Erectile dysfunction (ED) is described in the annals of history as early as 2000 BCE on Egyptian papyrus. 1 Despite advances in modern medicine, ED continues to plague men across all cultures and regions of the world. Low-dose gabapentin may result in marked sexual dysfunction, including loss of libido, erectile dysfunction, ejaculatory dysfunction, and anorgasmia. Such sexual dysfunction may lead to medication noncompliance. Patients often do not volunteer information regarding sexual dysfunction, and therefore, targeted questions are necessary. The frequency of this adverse effect is unknown, although sexual side effects were reported as uncommon in clinical trials when epilepsy was treated. It is unknown if gabapentin might affect other areas of sexual functioning, although, in this man, it did not. Common Side Effects. Gabapentin is fairly safe when you take it according to doctors’ prescriptions. However, you may experience a few side effects. Some of the most common ones include the following: Dementia; Blurred vision; Loss of strength; Flu; Swelling of the feet or hands; Hoarseness; Delusions; Lower back pain; Side Effects that On only duloxetine and the increased bupropion, the patient also denied any further depressive or anxiety features. Of note, the patient's wife later contacted the treating psychiatrist to ensure that the patient had explained all of the sexual adverse effects associated with gabapentin and that he had discontinued this medication. Unfortunately gabapentin can cause impotence. Side effects of the Urogenital System: Infrequent: urinary tract infection, dysuria, impotence, urinary incontinence, vaginal moniliasis, breast pain, menstrual disorder, polyuria, urinary retention Other Side Effects of Gabapentin. In addition to sexual dysfunction, gabapentin may also cause other side effects. Common side effects of gabapentin include: Dizziness. Somnolence (drowsiness, lethargy and a strong desire to sleep) Peripheral edema (swelling of the hands and/or lower legs) This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation, anorgasmia, and impotence) at a total daily dose of only 300 mg. Sexual dysfunction is a key adverse effect leading to medication noncompliance. Psychotropic drugs associated with sexual dysfunction include antiepileptic drugs, antidepressants, and antipsychotics. Gabapentin, frequently used off-label to treat psychiatric and pain disorders, has previously been reported to cause sexual dysfunction at a minimum total daily dose of 900mg. This report Gabapentin could cause erectile dysfunction, sexual desire changes and ejaculatory dysfunction. There’s evidence that gabapentin may affect a man’s ability to reach orgasm (either by causing premature ejaculation or delayed ejaculation), especially if he’s older. Gabapentin can cause erectile dysfunction in men. Research on the use of gabapentin and ED in men is extensive, with various studies showing that the use of this medication can affect male users’ ability to get and keep an erection as well as experience an orgasm.
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