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When compared with the nondrug condition, both medications resulted in significantly worse performance on tests of verbal memory and motor speed, and participants reported a high incidence of sedative effects. Frequently reported side-effects for gabapentin included fatigue, unsteadiness, and dizziness. While very effective for certain indications, gabapentin unfortunately can have many adverse central nervous system effects in addition to memory loss including: Drowsiness; Dizziness; Amnesia; Memory impairment; Disorientation; Emotional Lability Studies have shown that gabapentin alone does not cause memory loss or impairment when used for long-term treatment. However, some patients may experience brain fog or slight confusion as potential side effects. Rare but serious side effects of gabapentin include: rash, itching, or yellowing of the skin; swelling of the face and throat, a condition called angioedema; problems speaking or swallowing; changes in memory, ability to concentrate, or personality. Gabapentin may cause breathing problems in people who use opioid pain medicines and those with Fortunately, memory loss and other side effects associated with gabapentin are not considered permanent and should resolve upon discontinuation of therapy or with a dose decrease. Please reach out to your doctor regarding the side effects you are experiencing and the high doses you are taking, which are far beyond your prescribed therapy and Some studies show that gabapentin may have effects on your memory. But we need more research on this topic to be sure. Still, older adults are more at risk of memory issues and medication side effects in general. A 2022 study looked at 480 adults aged 65 and older who were taking gabapentin. Explore gabapentin's effects on mental function, memory, and cognition. Learn about managing side effects and balancing therapeutic benefits with potential risks. A report from ISMP QuarterWatch (March 27, 2019) warns about the inappropriate use of GABA drugs like gabapentin and pregabalin. Mental impairment, confusion and memory loss are recognized side effects. Some people use the term fuzzy thinking to describe the brain impact. Memory loss caused by Gabapentin may improve or resolve after stopping the medication, but not everyone will experience a complete recovery. Strategies such as using memory aids, practicing good sleep hygiene, exercising regularly, maintaining a healthy diet, and considering cognitive rehabilitation therapy can help manage memory issues. Some of the most common Gabapentin long-term side effects include: Memory loss: Long-term gabapentin use has been linked to problems with memory and difficulty concentrating. Consult your physician if you have concerns about gabapentin and memory loss. Gabapentin is approved to prevent and control partial seizures, relieve postherpetic neuralgia after shingles and moderate-to-severe restless legs syndrome. Learn what side effects to watch for, drugs to avoid while taking gabapentin, how to take gabapentin and other important questions and answers. Gabapentin use has been associated with memory loss and cognitive decline. Studies suggest that the risk of dementia may be higher in patients treated with gabapentin. It is important for patients and healthcare providers to be aware of the potential cognitive side effects of gabapentin. Because of the side effects of long-term treatment with these drugs, we decided to evaluate the chronic effect of gabapentin, pregabalin and baclofen alone and in combination on rat memory using ORT. The data of this study was compared with scopolamine that induces memory deficits in ORT model ( 18 ). Conclusion: Patients treated with gabapentin or pregabalin had an increased risk of dementia. Therefore, these drugs should be used with caution, particularly in susceptible individuals. Keywords: dementia, Alzheimer disease, cognitive impairment, gabapentin (GBP), pregabalin (PGB) Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Gabapentin generally has mild side effects in short-term use, but the long-term use of this drug has been linked to more serious side effects, including memory loss and cognitive impairments. This has raised questions about the safety of gabapentin use and whether it can cause memory problems. And as a consequence, memory and attention and sleepiness are common side effects of these medications,” says Aatif M. Husain, M.D., a professor of neurology and the division chief of epilepsy, sleep and neurophysiology in the department of neurology at the Duke University School of Medicine in Durham, North Carolina. Memory loss, minor memory impairment can happen to those who take gabapentin. In the package insert for the drug, it mentions that mild memory loss was a side effect that certain participants got, although it wasn't that common. About 2% of those in clinical trials had some form of cognitive impairment on the drug. Gabapentin, a medication commonly prescribed for nerve pain and seizures, has been linked to potential cognitive side effects, including memory loss. While its therapeutic benefits are well-documented, some individuals report experiencing forgetfulness or difficulty concentrating during its use. However, gabapentin seems to be different from the traditional antiseizure drugs, and the exact mechanism(s) through which gabapentin exerts both its clinical and potential side effects is still unknown. One hypothesis includes binding to the alpha2-delta subunit of the voltage-dependent calcium channel (Rose and Kam, 2002). Considering that
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