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Gabapentin (GBP) has gained wide acceptance in the treatment of pain, migraine, bipolar illness, and epilepsy. It has a relatively benign side effect profile, lacks significant drug interactions, is not liver metabolized, and is renally excreted. Herein three cases are presented that demonstrate wit Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. Finally, reports in general contraindicate the use of gabapentin in conditions such as myasthenia gravis and myoclonus. PubMed Central (PMC) é um repositório gratuito de artigos de pesquisa em ciências da vida e biomédicas. Adverse Effects. Gabapentin may cause certain adverse effects, which are listed below. Severe reactions: The severe adverse reactions include suicidality, depression, Stevens-Johnson syndrome, anaphylaxis, angioedema, erythema multiforme, rhabdomyolysis, and withdrawal seizure or withdrawal symptoms if the drug is discontinued abruptly. This activity outlines the indications, mechanisms of action, administration, significant adverse effects, contraindications, monitoring, and characteristics of gabapentin toxicity. Risks of gabapentin use are highest among those with a history of a substance use disorder and those concurrently taking opioids. While gabapentin has a place in psychiatry for a select few indications, the literature does not support its use for many studied diagnoses. Quintero GC: Review about gabapentin misuse, interactions, contraindications and side effects. J Exp Pharmacol. 2017;9:13–21. 10.2147/JEP.S124391 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ] One RCT found side effects in 31% of gabapentin group while 10% of patients taking placebo, including confusion, dizziness, nausea, dry mouth, fatigue, headache, blurred vision, and memory loss17. The other RCT reported adverse events in 40% of gabapentin group vs 23.1% in the placebo group, with similar side effects as Ryan et al. 17 reported. Conclusions about the side effects caused by gabapentin. Some of the side effects related to gabapentin are teratogenicity, hypoventilation, respiratory failure, deficits in visual field, myopathy, self-harm behavior, suicidal behavior, mitochondrial toxicity, somnolence, dizziness and asthenia. The gabapentin route of administration is a The 3 most common adverse events were dizziness, somnolence, and peripheral edema. Patients receiving gabapentin >or=1800 mg/d had a higher incidence of peripheral edema (7.5%) than those receiving gabapentin <1800 mg/d (1.4%) or placebo (1.6%) (P<0.002, gabapentin >or=1800 mg/d vs placebo). There were more adverse effects reported with pregabalin (36 effects) than with gabapentin (22 effects). Six pregabalin studies reported euphoria as a side effect, while no studies reported euphoria with gabapentin. This was the only side effect that may correlate with addictive potential. Gabapentin is 1 of many antiseizure medications available for the treatment of epilepsy in adults; however, there are potential risks associated with its use. Therefore, it is important to determine the place of therapy of gabapentin in the treatment of epilepsy. What Did We Do? Increasing evidence suggests potential for gabapentin misuse and related adverse events (e.g., respiratory depression, sedation, physical dependence, and depression) (Gomes et al., 2017; Slavova et al., 2018; Tomko et al., 2018; McAnally et al., 2020; Evoy et al., 2021). The majority of adverse events pertained to the nervous system (7 effects) or psychiatric (3 effects) disorders. There were more adverse effects reported with pregabalin (36 effects) than with gabapentin (22 effects). Six pregabalin studies reported euphoria as a side effect, while no studies reported euphoria with gabapentin. Gabapentin / adverse effects* Gabapentin / therapeutic use Humans Pain / drug therapy* Practice Guidelines as Topic There is increasing evidence of the potential to cause harm in vulnerable populations such as the elderly and increasing prevalence of abuse. The risk of respiratory depression in combination with opioids is of particular concern in the context of the current opioid crisis. Results: The review identified a spectrum of atypical side effects associated with gabapentin use, ranging from neurological manifestations like myoclonus and ataxia to behavioral changes such as pediatric aggression and suicidal ideation. Background: Gabapentin is commonly used to treat neuropathic pain (pain due to nerve damage). This review updates a review published in 2014, and previous reviews published in 2011, 2005 and 2000. Objectives: To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain in adults. Gabapentin can induce diverse side effects such as teratogenicity, hypoventilation, respiratory failure, deficits in visual field, myopathy, self-harm behavior, suicidal behavior, mitochondrial toxicity, somnolence, dizziness and asthenia; these can be related to the route of administration. Side effects tend to be mild to moderate in intensity, most frequently affect the central nervous system, and resolve with time in many individuals. GBP has been prescribed for approximately 70,000 individuals worldwide without untoward incidence of severe systemic toxicity to date.
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