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Summary: Sleep apnea syndrome is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Xyrem, and have Narcolepsy. Common side effects when using gabapentin as a sleep aid can include dizziness, drowsiness, and fatigue. These effects may be more pronounced in the beginning of treatment and often subside as the body adjusts to the medication. Health care professionals and patients should also report side effects from gabapentin, pregabalin, or other medicines to the FDA’s MedWatch program. Patients and caregivers should seek medical attention immediately if you or someone you are caring for experiences symptoms of respiratory problems, because these can be life-threatening. People who are taking opioids for chronic conditions, like cancer or chronic obstructive pulmonary disease (COPD), may be more at risk of sleep apnea complications. More research is needed to understand opiate effects and the type of sleep apnea that may be at work. Obstructive sleep apnoea (OSA) is characterized by repeated episodes of apnoea and hypopnoea during sleep. Little is known about the potential impact of therapy drugs on the underlying respiratory disorder. Any influence should be taken into account and appropriate action taken, including drug withdrawal if necessary. in breathing during sleep. The three observational studies at one academic medical center professionals to report side effects involving gabapentin, pregabalin, or other medicines Although drugs with sedative properties may increase the risk of airway collapse during sleep, their acute effects on the apnea-hypopnea index in older adults are under-reported. We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. The potential benefits of gabapentin for sleep must be carefully weighed against its risks and side effects. For those considering gabapentin as a sleep aid, it’s crucial to consult with a healthcare professional who can provide personalized advice based on individual health history, sleep patterns, and specific sleep concerns. Regardless the type of sleep outcomes, gabapentin showed stable efficacy in the treatment for sleep disturbance in patients with medical illness with a relatively high risk of treatment discontinuation and drug withdrawal when used at an average dose of approximately 1,800 mg/day. Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. The objective of this systematic review and meta-analysis was to asse RE: Gabapentin and sleep apnea (08-28-2014, 02:32 AM) archangle Wrote: Be very careful about Gabapentin. Take it according to directions, and watch out for the side effects. The main adverse effects reported with gabapentinoids are sleepiness, dizziness, headache, nausea, and vomiting. Due to the structural similarity between gabapentin and baclofen (a centrally acting GABA-B agonist), gabapentin was reported to produce “baclofen-like” effects [1] (Figure 1A). We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. A double-blind, randomized, placebo-controlled cross-over pilot study using a bedtime dose of gabapentin 300 mg was conducted in eight non-obese older men. Polysomnography measured the effects of the intervention. Health care professionals and patients should report side effects from gabapentin, pregabalin or other medicines to the FDA’s MedWatch program. Additional Resources. Opioid Medications; One trial showed that using pregabalin alone and using it with an opioid pain reliever can depress breathing function. 7,8 The other trial showed gabapentin alone increased pauses in breathing The main adverse effects reported with gabapentinoids are sleepiness, dizziness, headache, nausea, and vomiting. Due to the structural similarity between gabapentin and baclofen (a centrally acting GABA-B agonist), gabapentin was reported to produce “baclofen-like” effects [1] (Figure 1A). Common adverse reactions include dizziness, drowsiness, fatigue, and peripheral edema. These side effects can be particularly relevant when considering the medication’s potential impact on sleep patterns and respiratory function. The study found that gabapentin did not significantly worsen sleep apnea symptoms or increase the frequency of sleep apnea events. Another study published in The American Journal of Respiratory and Critical Care Medicine in 2019 investigated the effects of gabapentin on sleep apnea in patients with restless legs syndrome. However, misusing gabapentin can lead to more severe sleep-related side effects. Plus, those taking gabapentin for reasons other than insomnia may find the drowsiness uncomfortable. If you or someone you love is taking gabapentin without a prescription or struggling with substance use, Zinnia Health can offer the guidance you need. Central sleep apnea (CSA) is a potentially serious and under-recognized adverse reaction of opioids, baclofen, valproic acid, sodium oxybate, gabapentin, and ticagrelor. CSA may be associated with impaired sleep quality, insomnia, nonrestorative sleep, impaired quality of life, fatigue, daytime sleepiness, and increased morbidity and mortality
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