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Gabapentin, commonly prescribed for conditions such as epilepsy and neuropathic pain, has gained attention recently for its potential to cause sleepwalking. Sleepwalking, although often considered a harmless quirk, can pose various risks and disruptions to an individual's well-being. The results also have implications for prescribers to consider sleepwalking as a potential adverse effect and ensure that: 1) the patient is educated about a safe sleep environment; 2) they are encouraged to report the onset or exacerbation of sleepwalking, and 3) alternative treatments are considered if sleepwalking occurs. It is hypothesized that gabapentin may cause somnambulism, given its effect on sleep architecture and anecdotal reports. Somnambulism, or sleepwalking, is a parasomnia occurring during Non-Rapid Eye Movement (NREM) sleep. Due to the structural similarity between gabapentin and baclofen (a centrally acting GABA-B agonist), gabapentin was reported to produce “baclofen-like” effects [1] (Figure 1A). Like baclofen, some studies have shown that gabapentin might be of interest in alcohol dependence management [ 2]. Although there are no reports of somnambulism associated with gabapentin, it is hypothesized that gabapentin may cause somnambulism, given its effect on sleep architecture and anecdotal reports. Somnambulism, or sleepwalking, is a parasomnia occurring during Non-Rapid Eye Movement (NREM) sleep. There are no FDA-approved medications to treat sleepwalking. But there are medications that may be useful. They include: Gabapentin, a drug used for epilepsy, alters neurotransmitters and may Sleep walking is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Xyrem, and have Narcolepsy. Compared with the placebo group, the gabapentin group showed significant improvement in sleep quality (P < 0.001), next-day functioning (P < 0.001), number of nighttime awakenings caused by RLS symptoms (P = 0.043), and number of hours awake due to RLS symptoms (P = 0.019) after 12 weeks of treatment; the gabapentin group had a significantly I thank Lopez et al. for providing further insight on the topic of sleepwalking (SW), a common, occasionally injurious disorder for which there is scant therapeutic evidence. 1,2 In their letter responding to my editorial, “Darwin's Predisposition and the Restlessness that Drives Sleepwalking,” 3 Lopez et al. report on their data demonstrating an absence of a link between isolated SW and Gabapentin is safe and effective in improving the sleep quality of patients with sensory nervous-system diseases. Due to the limitations of sample size and types of diseases in the current study, the field needs multicenter, large-sample, and high-quality RCTs for further validation in the future. Somnambulism is the medical term for sleepwalking, which includes undesirable actions such as walking, occurring during abrupt but limited arousals from deep non-rapid eye movement (NREM) and slow-wave sleep.[1] Somnambulism is characterized by: Gabapentin interacts with α 2 δ subunits of voltage-gated calcium channels 1 and is approved for the management of postherpetic neuralgia and restless legs syndrome (RLS), and as adjunctive therapy for the treatment of partial seizures with and without secondary generalization (with maximal daily doses ranging from 600 to 1,800 mg, depending on indication and drug formulation). 2,3 In This research highlights the importance of considering sleepwalking in risk profiles in clinical trials, particularly for drugs that enhance GABA activity at the GABA A receptor, enhance serotonergic activity, or block the activity of noradrenaline at β receptors. Gabapentin and sleep. Most studies show that gabapentin improves slow wave sleep (“deep sleep”) and total sleep time. Two small studies showed that gabapentin may help people with primary insomnia and occasional sleep disturbance improve total sleep time and wakefulness in the morning. Gabapentin (a GABA analog enhancing GABA synthesis) and structurally related pregabalin, known as gabapentinoids, are both used in the treatment of epilepsy and neuropathic pain. The main adverse effects reported with gabapentinoids are sleepiness, dizziness, headache, nausea, and vomiting. Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. The objective of this systematic review and meta-analysis was to asse Twenty-nine drugs, primarily in four classes—benzodiazepine receptor agonists and other gamma aminobutyric acid (GABA) modulators, antidepressants and other serotonergic agents, antipsychotics, and β-blockers—were identified as possible triggers for sleepwalking. stop gabapentin and assess for resolution of sleepwalking. If sleepwalking resolves, a retrial of gabapentin and subsequent return of somnambulism would implicate gabapentin as the cause. However, if somnambulism persists in the absence of gabapentin, then this would suggest that gabapentin is not the cause. Throughout the study, investigators I can say I have not experienced sleepwalking with Gabapentin,but did sleepwalk when I was on a higher dose of ambien.I was sleepwalking and eating in my sleep lol. Gabapentin effected my memory a little,so i decided to stop it.It does help with sleep and nerve pain for many. Gabapentin and Sleep Walking Gabapentin, primarily used to treat epilepsy and neuropathic pain, has also been associated with sleepwalking in some cases. Originally developed as an anticonvulsant, gabapentin has found off-label use in treating various conditions, including anxiety disorders and insomnia.
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