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I‘m 22 years old and suffering from depression and social anxiety since I was 15. I tried over 13 different medications, 2 depth psychological therapies and 1 behavioral one. Nothing helped. Well, I thought but today I remembered that there was one that helped me a little bit with Social Anxiety. It was Gabapentin (Neurontin). Randomized controlled trials in patients with anxiety disorders found that gabapentin is effective in treating social phobia . Gabapentin was generally not effective in treatment of panic and agoraphobia symptoms. However, a subgroup of more severely ill patients, particularly women, did show some improvement . A significant reduction (p < 0.05) in the symptoms of social phobia was observed among patients on gabapentin compared with those on placebo as evaluated by clinician- and patient-rated scales. Results were similar for the intent-to-treat and week-2 completer populations. A very small study also found that gabapentin was helpful for treating social anxiety disorder. Overall, there haven’t been any large, well-designed studies that compare gabapentin to first-choice anxiety medications , such as selective serotonin reuptake inhibitors (SSRIs). Gabapentin, originally developed as an anti-seizure medication, has shown promising results in managing social anxiety disorder. While it’s not yet FDA-approved specifically for social anxiety, numerous studies have highlighted its potential benefits. A recent meta-analysis examined the effectiveness of gabapentin for various anxiety Gabapentin, while slower, may still be effective for individuals with specific anxiety profiles, such as social anxiety. It may also be a better option for individuals who have both anxiety and chronic pain or those seeking a medication with a lower risk of misuse. To test the efficacy of Gabapentin and Tiagabine for the treatment of social anxiety disorder, researchers recruited 8 adult participants (21 to 39 years old). All participants had been diagnosed with social anxiety disorder in accordance to DSM-IV criteria and had scores exceeding 30 on the Liebowitz Social Anxiety Scale (LSAS). Gabapentin and pregabalin both have RCTs showing efficacy over placebo for social anxiety disorder; however, it should be noted that improvement was associated with higher doses than are often tolerated (e.g., >2,100 mg daily for gabapentin and 600 mg total daily for pregabalin) (113–115). Multiple RCTs have shown gabapentin to be ineffective for bipolar disorder. There is insufficient evidence to recommend the use of gabapentin for MDD, GAD, PTSD, or OCD. There is sufficient evidence to consider the use of gabapentin for social anxiety disorder and, potentially, severe panic disorder after other treatment options have failed. Based on some promising studies, some scientists and doctors agree that it may be helpful for treating social anxiety disorder and severe panic disorder (frequent panic attacks) in people who don’t respond to other treatments. Although evidence is limited, some studies show gabapentin can help with anxiety symptoms. One 2020 review suggests gabapentin may help with different types of situational anxiety, This small study adds to the existing database stating that the anticonvulsants gabapentin and tiagabine can be efficacious in the treatment of social anxiety disorder, with a favorable side effect profile compared to the selective serotonin reuptake inhibitor and benzodiazepine treatment choices. Gabapentin and pregabalin are structurally related compounds which are classified as gamma-aminobutyric acid (GABA) analogues or gabapentinoids (Figure 1).Gabapentin, which received American Food and Drug Administration (FDA) approval in 1993, is indicated for the treatment of postherpetic neuralgia, and as adjunctive therapy for refractory partial-onset seizures. Neurontin (gabapentin) "Neurontin has changed my life dramatically. I suffered from high anxiety with panic and anxiety attacks. I started this medicine at about 19 and had been off and on it the past 13 years. It literally has made me a new person. When I don't use it, I notice a lot of fatigue, worry, anxiety, etc. If you struggle with anxiety, you may be prescribed gabapentin to help to control your symptoms. Here’s what you need to know about anxiety, how gabapentin might help, how long it might take to start working, and what side effects or special precautions you need to be aware of while under medication. For these reasons, gabapentin has been embraced as a possible treatment for anxiety disorders. Anxiety is a common mental health challenge that features an outsized response to feeling threatened or afraid. The fear response is out of proportion to the actual threat, resulting in a rush of stress hormone production. Social anxiety disorder (SAD) is characterized by a fear of negative evaluation in social or performance situations and a strong tendency for sufferers to avoid feared social interactions or situations. Recent epidemiological studies suggest that the lifetime prevalence of SAD may be as high as 12% (Grant et al. 2005; Kessler et al. 1994, 2005a). Gabapentin is thought to work by affecting neurotransmitters in the brain, like gamma-aminobutyric acid (GABA). GABA helps regulate anxiety and stress responses in the brain, so increasing levels can cause a calming effect, reducing feelings of anxiety and promoting relaxation. Gabapentin appears to have some benefit for anxiety disorders but failed to show benefit in bipolar disorder trials. In the individual patient with a mixed psychiatric disorder, benefits are most likely due to anxiolytic effects. I got like really good sleep and it took social anxiety away and all that good stuff, then I started noticing that I was more depressed than usual, so after withdrawaling from it for a couple weeks with pretty bad insomnia and a few other symptoms, the depression lifted and memory came back to where it was before starting gabapentin.
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