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Pain management after total knee arthroplasty (TKA) varies and has been widely studied in recent years. Some randomized controlled studies have carried out to evaluate the effects of gabapentin on pain relief after TKA. The pooled results show no evidence to support the routine use of gabapentin in postoperative pain control after total knee arthroplasty or total hip arthroplasty. The VAS as a common and effective indicator for pain rating was applied to assess the pain level for patients undergoing THA or TKA (0–100 or 0–10, 0 was no pain and 10 or 100 Perioperative gabapentin reduces 24 h opioid consumption and improves in-hospital rehabilitation but not post-discharge outcomes after total knee arthroplasty with peripheral nerve block The American Association of Hip and Knee Surgeons (AAHKS), The American Academy of Orthopaedic Surgeons (AAOS), The Hip Society, The Knee Society and The American Society of Regional Anesthesia and Pain Medicine (ASRA) have worked together to develop evidence-based guidelines on the use of gabapentinoids in primary total joint arthroplasty (TJA). Gabapentin is routinely used in preoperative multimodal anesthesia to reduce pain following total joint arthroplasty (TJA) surgery. Evolving evidence has shown it is ineffective in reducing postoperative pain and should be used cautiously in this patient population due to its adverse effects. Gabapentin (Neurontin) or pregabalin (Lyrica): These are medications that specifically treat certain seizures and nerve pain. However, doctors may prescribe Trusted Source. pain after the Perioperative gabapentin reduces 24 h opioid consumption and improves in-hospital rehabilitation but not post-discharge outcomes after total knee arthroplasty with peripheral nerve block The efficacy of perioperative gabapentin for the treatment of postoperative pain following total knee and hip arthroplasty: a meta-analysis. J Orthop Surg Res 2020; 15:332. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ] A total of 1805 patients aged 18 to 75 years scheduled for surgery (thoracotomy, video-assisted thoracoscopic surgery, total hip replacement, total knee replacement, mastectomy, breast lumpectomy, hand surgery, carpal tunnel surgery, knee arthroscopy, shoulder arthroplasty, and shoulder arthroscopy) were screened. Pregabalin is accepted to be more potent, and with fewer adverse effects, than its class counterpart gabapentin. It has fast gastrointestinal absorption, a high bioavailability, and its serum representation is dose-proportional leading to a predictable and near-linear pharmacokinetic profile. 6 The maximum plasma concentration is reached at 1 h after oral administration, and its elimination We would like to show you a description here but the site won’t allow us. The literature search was conducted by following databases: Medline, Cochrane database, ClinicalTrials.gov, PubMed, and Embase. The following keywords including pain management, postoperative pain, total knee arthroplasties, total knee replacement, and gabapentin were used for searching. 1. Inclusion criteria. Studies were considered eligible Postoperative pain after total knee arthroplasty (TKA) and total hip arthroplasty (THA) influence patients’ rehabilitation and life quality. Although gabapentin has been widely used for analgesia, its efficacy is still controversial in TKA and THA. Total knee replacement is acknowledged as a successful and durable operation, but recovery from this surgery is often lengthy and painful. A great deal of attention has recently been directed at enhancing this recovery, most of which has focused on improvements in perioperative pain control. Various protocols have been suggested. Abstract. Gabapentin is routinely used in preoperative multimodal anesthesia to reduce pain following total joint arthroplasty (TJA) surgery. Evolving evidence has shown it is ineffective in reducing postoperative pain and should be used cautiously in this patient population due to its adverse effects. The key words and medical subject heading terms included the following: gabapentin, pain control, total knee arthroplasty, total knee replacement, TKA, and TKR. These key words and the corresponding medical subject heading terms were combined with the Boolean operators AND and OR. Gabapentin resulted in less total patient-controlled analgesia (PCA) morphine use over 48 hours postoperatively (P<0.05), better active knee flexion on postoperative days (PODs) 2 and 3 (P<0.05 for both), and less pruritus (P<0.05) than placebo.¹⁰ Clarke HA, Katz J, McCartney CJ, et al. Perioperative gabapentin reduces 24 h opioid consumption and improves in-hospital rehabilitation but not post-discharge outcomes after total knee arthroplasty with peripheral nerve block. Active knee flexion post-total knee arthroplasty shown for patients who received postoperative gabapentin versus placebo. Patients who received postoperative gabapentin versus placebo had significantly better active knee flexion on postoperative day (POD) 2 (71°±12° versus 59°±12°) and POD 3 (80°±9° versus 70°±9°), with a trend Perioperative and postoperative pain protocols after total knee arthroplasty. PONV, postoperative nausea and vomiting. tissues, they do not require a particular skill set, and, importantly, they do not cause motor blockade, which enables patients to be more active earlier.
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