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Urinary retention (UR) is a urological syndrome characterized by the patient’s inability to empty all the urine from the bladder. It is usually caused by obstructive diseases of the lower urinary tract (eg, benign prostatic hyperplasia [BPH] and urethral stricture), urinary tract infections and/or inflammatory diseases, and neurological disorders (eg, diabetic neuropathy, multiple sclerosis I am a 66 year old male taking gabapentin for sciatic pain. I have noted a strong correlation of trouble urinating and taking gabapentin. I take it at night and have substantial problems urinating in the morning and for a couple of hours after I get up. Urinary hesitancy can be an adverse event associated with levomilnacipran treatment. Areas covered: This manuscript details the longitudinal course of levomilnacipran-induced urinary hesitancy in 2 cases that were in a pivotal clinical trial, examining possible predisposing factors and treatment issues. This manuscript also reviews the Physicians who administer gabapentin should inform their patients about the potential risk of gabapentin-induced incontinence and its negative impact on quality of life. Gabapentin is a first-line agent for neuropathic pain management and has a favorable safety profile. To the best of our knowledge, the literature includes just 5 cases of gabapentin-induced incontinence, 3 of which involved both rectal and urinary incontinence and 2 involved only urinary incontinence. Urinary retention is the acute or chronic inability to voluntarily pass an adequate amount of urine. The condition predominantly affects men. The most common causes are obstructive in nature, with limited autonomy, this urinary distress can determine a complete social withdrawal.3,4 Many of these patients need continuous and fairly expensive home care. In many coun-tries, especially the United States, urinary distress in neurogenic patients is responsible for 40% to 60% of all nursing-home admis-sions, with very high costs for public health Physicians who administer gabapentin should inform their patients about the potential risk of gabapentin-induced incontinence and its negative impact on quality of life. Yes, gabapentin can cause urinary incontinence, though it is considered a rare side effect. While the medication is primarily known for treating nerve pain, seizures, and restless legs syndrome, some individuals may experience a disruption in their bladder control while taking it. The literature includes a few cases suggesting an association between gabapentin use and urinary incontinence. This case focuses on a previously unrecorded association between gabapentin and increased urinary frequency, which was dose dependent. AUR is a urologic emergency that requires immediate treatment by insertion of a urinary catheter that allows the bladder to empty. Potential complications of an AUR event are pain, loss of bladder contractibility, urinary tract infections, kidney damage, incontinence, urosepsis, increased risk of another episode of AUR, and psychologic distress. Gabapentin (GBP) is a structural analog of gamma-aminobutyric acid (GABA) that is commonly used in palliative care for symptom management indications including neuropathic pain syndromes, hiccups, cough, and anxiety. An uncommon adverse effect of GBP is urinary incontinence (UI). We report the case In frequent urination caused by gabapentin, the urine is usually colorless and does not have any particular smell, but if your urine is usually dark in color or has any significant smell, you need to reach out to your healthcare provider to rule out any underlying health condition. Note: This document provides detailed information about Neurontin Side Effects associated with gabapentin. Some dosage forms listed on this page may not apply specifically to the brand name Neurontin. Applies to gabapentin: oral capsule, oral solution, oral suspension, oral tablet, oral tablet extended release 24 hr. Serious side effects of Ten days after she began taking gabapentin to relieve her pain, she experienced daily urinary incontinence. In another instance, a 63-year-old female patient was diagnosed with complex regional pain syndrome, and seven days after the initiation of gabapentin therapy, urinary incontinence developed. Studies show gabapentin might cause urinary incontinence, especially in certain patients. Knowing who is most affected highlights the need for careful monitoring. Many case studies have found patients getting urinary incontinence after taking gabapentin. In the following day, she complained of urinary incontinence with the absence of dysuria and urgency. It was not worse with movement, coughing, sneezing, or laughing. The vaginal parity of the patient was one. Gabapentin and Urinary Retention To determine whether there is any evidence to support an (causal) association between the administration of gabapentin and the development of urinary retention. Download PDF Urinary hesitancy is when you have difficulty peeing, including trouble starting, a slow urine flow or dribbling. There are many causes, but benign prostatic hyperplasia (BPH) is the most common. Drug-induced urinary retention is generally treated by urinary catheterization, especially if acute, in combination with discontinuation or a reduction in dose of the causal drug.
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