Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. For healthcare professionals. Applies to gabapentin: compounding powder, oral capsule, oral solution, oral tablet, oral tablet extended release. General adverse events. The most common adverse reactions associated with the use of this drug were dizziness, somnolence, and peripheral edema. Gabapentin is a medication used to treat seizures, restless legs syndrome, and nerve pain from shingles. Some people taking it report fluid retention and swelling in their extremities. Swelling may be more likely if you’re older, or if you’re taking a higher gabapentin dosage . Gabapentin’s primary use is to prevent or control seizures. It works by calming nerve activity to reduce seizure intensity or occurrence. Children and adults can take this drug. Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect of another drug. Yes, gabapentin may cause fluid retention and induce edema in arms and legs. Experts believe that this side effect can also be the reason for weight gain by increasing your water weight. It can also make the body look bulky. Gabapentin does help with the pain but, I don’t like the swelling. It also makes me drowsy but I sleep good. The drug has pros and cons about it. I have been on it for about 8.5 years with no fluid retention or other side effects. Thanks for your response but Im not 100% convinced that is true. Gabapentin belongs to the group of medicines known as anticonvulsants. 2. Upsides. May be used in addition to other medication to reduce seizure frequency in adults and children aged three and older with partial-onset seizures. May be used in the management of postherpetic neuralgia (persistent nerve pain following Shingles infection) in adults. Gabapentin is a common drug used as analgesic and anticonvulsant and also is prescribed for insomnia, depression, obsessive – compulsive disorder and panic attack. We report a case of a 48-year-old man who is prescribed gabapentin because of insomnia, headache, and depressed mood. Dietary Changes: Reducing salt intake can help minimize fluid retention. Elevating Extremities: Keeping swollen limbs elevated can assist in reducing discomfort. Adequate Hydration: Staying hydrated helps maintain proper kidney function and fluid balance. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. Using gabapentin alongside medications like NSAIDs (non-steroidal anti-inflammatory drugs), certain anti-arrhythmics, or opioids used for pain relief can increase the risk of fluid retention, worsen existing heart failure, and may decrease the effectiveness of the other medications. Careful consideration of drug interactions is therefore Gabapentin (Neurontin) is a medication that’s FDA approved to treat seizures and postherpetic neuralgia (nerve pain from shingles). Gabapentin can cause fluid buildup in the legs (edema), which can lead to temporary weight gain. You can also gain weight without fluid buildup, though it’s not common. Gabapentin is also used off-label to treat conditions such as anxiety and nerve pain from diabetes. It may also be used to treat alcohol use disorder. Though gabapentin has many potential uses, it can cause side effects too. Knowing about gabapentin side effects in advance can help you manage them if they happen to you. Background. Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of indications both Food and Drug Administration approved and off-label. 1-3 It is approved by the Food and Drug Administration to treat postherpetic neuralgia and epilepsy 4 with common off-label indications including fibromyalgia, anxiety, mood disorders, and What is gabapentin and what is it used for? Gabapentin is used to control seizures, to treat nerve pain that can happen after having had shingles , and to treat a condition called restless legs syndrome. Background Gabapentin and pregabalin are commonly prescribed medications to treat pain in patients with diabetic neuropathy. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. This study aims to 1. Does gabapentin cause water retention in the legs? Yes, gabapentin is associated with peripheral edema, leading to fluid retention and swelling in the legs and feet. The risk is generally considered dose-related and more common in elderly patients. 2. How long does gabapentin edema last? Fluid retention, or edema, can occur when gabapentin affects vascular permeability or alters kidney function. Edema refers to swelling caused by excess fluid accumulation in tissues. It can occur in various parts of the body but is most commonly seen in the legs, ankles, and feet. Thus, unlike gabapentin, the EMA’s assessment of this risk leads a warning for the use of pregabalin in patients who are cardiovascular compromised due to the potential risk of developing/worsening congestive heart failure [35] The only known pharmacological difference between these two drugs is a stronger dose-response effect with pregabalin
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