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Background: Few direct head-to-head comparisons have been conducted between drugs for the treatment of diabetic peripheral neuropathic pain (DPNP). Approved or recommended drugs in this indication include duloxetine (DLX), pregabalin (PGB), gabapentin (GBP) and amitriptyline (AMT). This meta-analysis aims to compare the efficacy and safety of duloxetine and gabapentin in the treatment of diabetic peripheral neuropathic pain (DPNP) and therefore to provide evidence-based medicine for clinical treatment. For neuropathic pain (mainly diabetic peripheral neuropathy and postherpetic neuralgia), the anticonvulsants gabapentin, pregabalin, and oxcarbazepine produced small improvements in pain in Pain is the most troublesome symptom of DPNP, increasingly recognized as an important and independent feature of DPNP. This meta-analysis aims to compare the efficacy and safety of duloxetine and gabapentin in the treatment of diabetic peripheral neuropathic pain (DPNP) and therefore to provide evidence-based medicine for clinical treatment Pain is the most troublesome symptom of DPNP, increasingly recognized as an important and independent feature of DPNP. This meta-analysis aims to compare the efficacy and safety of duloxetine and gabapentin in the treatment of diabetic peripheral neuropathic pain (DPNP) and therefore to provide evidence-based medicine for clinical treatment Duloxetine has antidepressant, anti-anxiety, and pain-relieving properties; however, it may cause a discontinuation syndrome on withdrawal even when tapered. Symptoms may include anxiety, headache more. Gabapentin is an anticonvulsant with pain-relieving effects that may be used to treat certain seizure disorders or relieve nerve pain. Duloxetine is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Some brands of duloxetine are also used to treat fibromyalgia (a chronic pain disorder). Drizalma is for treating fibromyalgia only in adults. Comparative safety and tolerability of duloxetine vs. pregabalin vs. duloxetine plus gabapentin in patients with diabetic peripheral neuropathic pain. Irving G, Tanenberg RJ, Raskin J, Risser RC, Malcolm S. Int J Clin Pract. 2014;68:1130–1140. doi: 10.1111/ijcp.12452. [Google Scholar] 17. Tanenberg RJ, Irving GA, Risser RC, et al., ed. Duloxetine, pregabalin, and duloxetine plus gabapentin for diabetic peripheral neuropathic pain management in patients with inadequate pain response to gabapentin: an open-label, randomized, noninferiority comparison. Background Few direct head-to-head comparisons have been conducted between drugs for the treatment of diabetic peripheral neuropathic pain (DPNP). Approved or recommended drugs in this indication include duloxetine (DLX), pregabalin (PGB), gabapentin (GBP) and amitriptyline (AMT). We conducted an indirect meta-analysis to compare the efficacy and tolerability of DLX with PGB and GBP in DPNP Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy). Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Both gabapentin and Cymbalta can be effective in reducing nerve pain, but their effectiveness varies among individuals and specific pain conditions. Some people respond better to one medication over the other. Discover the differences between gabapentin or duloxetine for nerve pain, fibromyalgia, and diabetic neuropathy. Learn about dosing, side effects, pros and cons, and patient experiences. According to a recent study published in The International Journal of Clinical Practice, there is no significant difference between the use of gabapentin or duloxetine for the treatment of A Cochrane review of combination therapy for neuropathic pain demonstrated that gabapentin and opioids provide better pain relief than gabapentin or opioids alone, but this was associated with increased levels of adverse events. The calculated NNT was 9.5 (5.0–86), and the NNH was 10 (6.5–25). Conclusion: The findings suggest that both duloxetine and gabapentin demonstrate similar effectiveness in managing diabetic neuropathic pain. Researchers publishing in JAMA Neurology describe the results of a unique trial in which 402 people with idiopathic sensory polyneuropathy were randomly assigned to one of four medications: duloxetine, mexiletine, nortriptyline, or pregabalin. Compare Gabapentin vs Duloxetine head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Gabapentin is an anticonvulsant with pain Gralise (gabapentin) and Cymbalta (duloxetine) are used to treat different types of neuralgia (nerve pain). Gabapentin is used postherpetic neuralgia from herpes zoster (nerve damage from shingles) and to treat seizure disorders. Objective: The safety and tolerability of three treatments for diabetic peripheral neuropathic pain (DPNP) were compared. Methods: A 12-week, randomized, open-label study confirming the non-inferiority of duloxetine (N = 138) vs. pregabalin (N = 134) and the combination of duloxetine plus gabapentin (N = 135) as the primary outcome was previously published.
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