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Background Few direct head-to-head comparisons have been conducted between drugs for the treatment of diabetic peripheral neuropathic pain (DPNP). Approved or recommended drugs in this indication include duloxetine (DLX), pregabalin (PGB), gabapentin (GBP) and amitriptyline (AMT). We conducted an indirect meta-analysis to compare the efficacy and tolerability of DLX with PGB and GBP in DPNP Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy). Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Conclusion: The findings suggest that both duloxetine and gabapentin demonstrate similar effectiveness in managing diabetic neuropathic pain. Compare Gabapentin vs Duloxetine head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Gabapentin is an anticonvulsant with pain Chronic pain is defined by the International Association for the Study of Pain as ongoing or recurrent pain that lasts beyond the usual course of acute illness or injury or more than three to six Compare Cymbalta vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Gabapentin is an anticonvulsant with pain Cymbalta (duloxetine): Both medications are good but they are different. Cymbalta (duloxetine) works on 2different sites than gabapentin. Both are recommended in chronic pain. Pain relief takes many forms. This Special Health Report, Pain Relief Without Drugs or Surgery, looks beyond the standard approaches of drugs and surgery and explores alternate pain-relief strategies, from acupuncture and mind-body therapies to spinal manipulation, physical and occupational therapies, herbal remedies, mindfulness meditation, and music therapy among others. Duloxetine is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Some brands of duloxetine are also used to treat fibromyalgia (a chronic pain disorder). Drizalma is for treating fibromyalgia only in adults. This meta-analysis aims to compare the efficacy and safety of duloxetine and gabapentin in the treatment of diabetic peripheral neuropathic pain (DPNP) and therefore to provide evidence-based medicine for clinical treatment. Cymbalta is also used to relieve the symptoms of fibromyalgia, a chronic pain disorder characterized by widespread pain, fatigue, and tenderness in certain areas of the body.In addition, Cymbalta is prescribed for peripheral neuropathy, a condition that causes nerve damage, resulting in numbness, tingling, and pain usually in the hands and feet. Duloxetine has antidepressant, anti-anxiety, and pain-relieving properties; however, it may cause a discontinuation syndrome on withdrawal even when tapered. Symptoms may include anxiety, headache more. Gabapentin is an anticonvulsant with pain-relieving effects that may be used to treat certain seizure disorders or relieve nerve pain. Discover the differences between gabapentin or duloxetine for nerve pain, fibromyalgia, and diabetic neuropathy. Learn about dosing, side effects, pros and cons, and patient experiences. Both gabapentin and Cymbalta can be effective in reducing nerve pain, but their effectiveness varies among individuals and specific pain conditions. Some people respond better to one medication over the other. According to a recent study published in The International Journal of Clinical Practice, there is no significant difference between the use of gabapentin or duloxetine for the treatment Conclusions: Duloxetine 60 mg once daily emerges as more effective than gabapentin 300 mg once daily in alleviating diabetic neuropathic pain. Furthermore, both pharmaceutical agents demonstrate favorable tolerability, albeit with gabapentin exhibiting superior tolerability compared to duloxetine. I'm taking 160 mgs duloxetine and 2400 mgs of gabapentin daily. So far I haven't had problems. The duloxetine is for severe depression caused by chronic pain and the gabapentin is for restless leg syndrome and nerve pain. Serious side effects of duloxetine. Along with its needed effects, duloxetine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking duloxetine: Incidence not known The mean duration of diabetes was 9.4 ± 3.5 years (range: 6-14 years). The duloxetine group had a longer mean duration of diabetes than the pregabalin group (10.3 ± 1.4 vs. 7.5 ± 1.9 years). Mean pain intensity recorded on VAS for duloxetine and pregabalin group on day 0, week 4, and week 12 are shown in Table 1. There was a statistically Gralise (gabapentin) and Cymbalta (duloxetine) are used to treat different types of neuralgia (nerve pain). Gabapentin is used postherpetic neuralgia from herpes zoster (nerve damage from shingles) and to treat seizure disorders.
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