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Although warfarin's interactions with other drugs have long been studied, the most recent review of the literature of warfarin's interactions with psychotropics was over a decade ago. Thus, we conducted a systematic review of the literature documenting the interaction between warfarin and psychotropics, with a focus on interactions mediated Does warfarin interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker. The largest first-trimester exposure differences between nonlive and live-birth pregnancies were observed for lithium (242 vs 89), gabapentin (1639 vs 653), and duloxetine (1914 vs 860). Steady increases in hydralazine and gabapentin exposures were observed during the study years, whereas atenolol exposure decreased (561 to 280). Carbamazepine appears to reduce warfarin's anticoagulant effect. Other antipsychotics, antidepressants and anxiolytics have only a theoretical risk of interaction. Lithium, gabapentin, sulpiride and amisulpride are predominantly renally excreted and so are not likely to interact with warfarin. Both Gabapentin and Chlordiazepoxide have effects on the CNS and can cause sedation, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing). In some cases, use of two or more drugs that have effects on the CNS might also increase the risk of CNS depressant effects (which could range from Increased Risk of Bleeding is Possible when Combining Warfarin With: Antiplatelets; Fish Oil/Omega 3 Fatty Acids; NSAIDs; Other Anticoagulants; Steroids; Vitamin E Coumadin Interactions. There are 664 drugs known to interact with Coumadin (warfarin), along with 8 disease interactions, and 5 alcohol/food interactions. Of the total drug interactions, 164 are major, 430 are moderate, and 70 are minor. Gabapentin is in the drug class gamma-aminobutyric acid analogs. A total of 653 drugs are known to interact with warfarin. Warfarin is in the drug class coumarins and indandiones. Applies to: warfarin. Nutrition and diet can affect your treatment with warfarin. Compare Gabapentin vs Warfarin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. The following list contains common medications that interact with warfarin (Coumadin), which may lead to decreased INR readings and thus, increased risk of clotting, strokes, and DVTs (i.e., blood is “not thin enough”). The patient's medications should be analyzed closely for drug interactions with warfarin, especially when initiating or altering therapy. The effect of a drug interaction can be unpredictable; thus, individuals receiving interacting medications are likely to require increased INR monitoring. Another review of warfarin drug–drug interaction reported that the concomitant use of warfarin with other medications, including cotrimoxazole, quinolones, amiodarone, macrolides, SSRIs, platelet aggregation inhibitors, NSAIDs and lipid-lowering agents, was associated with an increased risk of bleeding in patients 65 years and older. 96 Most We would like to show you a description here but the site won’t allow us. When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another Drug interactions are reported among people who take Warfarin sodium (warfarin sodium) and Gabapentin (gabapentin). Common drug interactions include arthralgia among females and abdominal distension among males. Using warfarin together with ethanol (alcohol) can cause you to bleed more easily. If you take warfarin you should avoid large amounts of alcohol, but moderate consumption (one to two drinks per day) are not likely to affect the response to warfarin if you have normal liver function. The study uses data from the FDA. It is based on warfarin sodium and gabapentin (the active ingredients of Coumadin and Gabapentin, respectively), and Coumadin and Gabapentin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Another review of warfarin drug–drug interaction reported that the concomitant use of warfarin with other medications, including cotrimoxazole, quinolones, amiodarone, macrolides, SSRIs, platelet aggregation inhibitors, NSAIDs and lipid-lowering agents, was associated with an increased risk of bleeding in patients 65 years and older. 96 Most Warfarin (Coumadin, Jantoven) is an oral medication used to prevent and treat blood clots. Your warfarin dosage is personalized to protect you from clotting problems, while also keeping you safe from bleeding problems. A large number of medications, supplements, and foods interact with warfarin. In a recent CMAJ commentary on drug interactions with warfarin, 1 David Juurlink overlooked a very important category of drugs that interact with warfarin: antiepileptic drugs.
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