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Both Sertraline and Gabapentin have effects on the CNS and can cause sedation, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing). In some cases, use of two or more drugs that have effects on the CNS might also increase the risk of CNS depressant effects (which could range from sedation Ways to counteract this sexual side effect of Zoloft include adding a drug that boosts dopamine, norepinephrine, and/or GABA. In your case, your doctor added gabapentin, which increased GABA activity, thereby leading to a reduction of the SSRI-induced sexual dysfunction. When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Zoloft and gabapentin are commonly prescribed medications that may interact with each other, potentially leading to increased side effects or decreased effectiveness. This article explores the potential interactions and provides guidance for individuals taking both medications. Sertraline Interactions. There are 672 drugs known to interact with sertraline, along with 10 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 157 are major, 510 are moderate, and 5 are minor. Concomitant use of gabapentin and other CNS depressants has resulted in serious, life-threatening, or fatal respiratory depression. Appropriate studies have not been performed on the relationship of age to the effects of sertraline in children with . depression, panic disorder, premenstrual dysphoric disorder (PMDD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD), and in children younger than 6 years of age with obsessive-compulsive disorder. Safety Yes, both Zoloft and Gabapentin can interact with other medications, so it’s essential to inform your healthcare provider about all drugs and supplements you’re taking to prevent potential interactions. ZOLOFT and other medicines may affect each other causing possible serious side effects. ZOLOFT may affect the way other medicines work, and other medicines may affect the way ZOLOFT works. Before taking ZOLOFT, tell your healthcare provider if you are pregnant or plan to become pregnant; breastfeeding or plan to breastfeed. Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [10] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [11] Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. An interaction with sertraline could cause a serious condition called serotonin syndrome. To make sure Zoloft is safe for you, tell your doctor if you have ever had: an allergy or sensitivity to aspirin or tartrazine (food dye) or latex (Zoloft oral solution only - the dropper dispenser contains natural rubber); The phase IV clinical study analyzes what interactions people have when they take Zoloft and Gabapentin, and groups them by gender, age and more. It is created by eHealthMe based on reports of 5,671 people who take the same drugs from the FDA, and is updated regularly. Compare Gabapentin vs Zoloft head-to-head with other drugs for uses, ratings, cost, side effects and interactions. A Moderate Drug Interaction exists between gabapentin and Zoloft. View detailed information regarding this drug interaction. Drug interactions are reported among people who take Sertraline (sertraline hydrochloride) and Gabapentin (gabapentin). Common drug interactions include malaise among females and chronic kidney disease among males. Sertraline side effects Common sertraline side effects. Common sertraline side effects are nausea, diarrhea, indigestion, loss of appetite, increased sweating, shaking or trembling, decreased appetite, inability to ejaculate, and decreased libido. These side effects occurred in 5% or more of patients using this medicine. Serious sertraline side The following applies to the ingredients: Sertraline (found in Zoloft) and Gabapentin Treatment with sertraline may occasionally cause blood sodium levels to get too low, a condition known as hyponatremia, and using it with some anticonvulsants can increase that risk. Do not drink alcohol while you take ZOLOFT. The most common side effects in adults treated with ZOLOFT include: nausea, loss of appetite, diarrhea, or indigestion; increased sweating; tremor or shaking; agitation; change in sleep habits, including increased sleepiness or insomnia; sexual problems, including decreased libido and ejaculation failure
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