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Memory impairment and cognitive decline are two of the greatest concerns with long-term administration of drugs that affect the CNS. In this study, we discovered a significant association between cumulative exposure to gabapentin and pregabalin and the risk of dementia. Gabapentin, a medication commonly prescribed for nerve pain and seizures, has been linked to potential cognitive side effects, including memory loss. While its therapeutic benefits are well-documented, some individuals report experiencing forgetfulness or difficulty concentrating during its use. Dizziness is the No. 1 side effect of gabapentin. In studies, almost 30% of people taking gabapentin for postherpetic neuralgia, and over 15% of people taking it for seizures, experienced dizziness. Neurontin (gabapentin) is associated with memory loss in a dose dependent fashion, meaning the higher doses you take, the more chance there is of having some sort of memory loss, or cognitive impairment. Abstract. Memory impairment is one of the greatest concerns when it comes to long-term CNS-affecting drug administration. Drugs like gabapentin, pregabalin and baclofen are administered in a long-term period in conditions such as epilepsy, neuropathic pain, spasticity associated with spinal cord injury or multiple sclerosis. Explore gabapentin's effects on mental function, memory, and cognition. Learn about managing side effects and balancing therapeutic benefits with potential risks. Some people taking gabapentin, mostly those with chronic kidney disease, have reported problems with short-term memory loss. However, it’s not clear if gabapentin is actually responsible for these brain function issues. One study found that gabapentin alone did not affect memory or cause memory impairment or memory loss. Nevertheless, more Fortunately, memory loss and other side effects associated with gabapentin are not considered permanent and should resolve upon discontinuation of therapy or with a dose decrease. Memory loss caused by Gabapentin may improve or resolve after stopping the medication, but not everyone will experience a complete recovery. Strategies such as using memory aids, practicing good sleep hygiene, exercising regularly, maintaining a healthy diet, and considering cognitive rehabilitation therapy can help manage memory issues. Here, we’ll delve into seven types of drugs that may cause memory loss and explore alternative treatment options. Short- vs. long-term memory There are two key types of memory: short- and long-term, says Jessica Merrey, the lead clinical pharmacy specialist at Johns Hopkins Hospital in Baltimore. In a cross-over study comparing cognitive effects of carbamazepine vs gabapentin in healthy adults, Meador et al. found that cognitive performance while taking gabapentin was statistically better than while taking carbamazepine in 8 out of 31 neuropsychological variables; however, when compared with performance while not taking either In people with partial seizures, gabapentin works by decreasing abnormal activity in the brain. Experts believe gabapentin may cause brain cells to produce more of a chemical called GABA, which reduces abnormal electrical activity of brain cells. Gabapentin, a medication commonly used for epilepsy and neuropathic pain, can cause memory problems in some individuals. Memory loss caused by Gabapentin may improve or resolve after stopping the medication, but not everyone will experience a complete recovery. While the evidence suggests that gabapentin alone does not cause memory loss, it can lead to brain fog or minor confusion. However, combining gabapentin with other drugs like baclofen can result in significant memory loss and impairment. Gabapentin use has been associated with memory loss and cognitive decline. Studies suggest that the risk of dementia may be higher in patients treated with gabapentin. It is important for patients and healthcare providers to be aware of the potential cognitive side effects of gabapentin. To truly grasp the cognitive effects of gabapentin, we need to don our neuroscience hats and dive into the brain’s inner workings. Gabapentin doesn’t play by the rules of most medications. Instead of directly latching onto neurotransmitters, it sneaks in through a back door, binding to calcium channels in our neurons. Abstract. Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., cognitive decline, functional status decline, and motor function change) in older adults. Memory loss and other cognitive adverse effects are well known to occur with gabapentin (brand name Neurontin) and they appear to be dose related, meaning higher doses result in a higher incidence rate. This study found that not only can Gabapentin cause memory loss when abused, but it can also lead to other cognitive problems that can contribute to memory impairment. Also, Gabapentin's long-term use side effects present other dangers, such as weakened muscles, fatal toxicity, and respiratory failure. Can Gabapentin cause memory loss? Yes, memory loss is a potential side effect of Gabapentin. While not experienced by everyone, some individuals may notice difficulties with memory or concentration while taking Gabapentin for pain and symptom management.
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