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We hypothesized that gabapentinoids might be associated with sleep apnea syndrome. A recent pilot study reported a higher apnea–hypopnea index with gabapentin, supporting our hypothesis [5]. Obstructive sleep apnoea (OSA) is characterized by repeated episodes of apnoea and hypopnoea during sleep. Little is known about the potential impact of therapy drugs on the underlying respiratory disorder. Any influence should be taken into account and appropriate action taken, including drug withdrawal if necessary. gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR) When used with CNS depressants or in patients with lung problems . in breathing during sleep. The three Regardless the type of sleep outcomes, gabapentin showed stable efficacy in the treatment for sleep disturbance in patients with medical illness with a relatively high risk of treatment discontinuation and drug withdrawal when used at an average dose of approximately 1,800 mg/day. One trial showed that using pregabalin alone and using it with an opioid pain reliever can depress breathing function. 7,8 The other trial showed gabapentin alone increased pauses in sleep apnea and central sleep apnea (CSA). Opioid use and comedications: There is an evident opioid crisis, which is primarily fueled by the illicit use of opioids.2 However, the misuse of opioids by patients with pain who are prescribed long-term opioid therapy may also potentially lead to fatal consequences. In 2016, the US Centers for Gabapentinoids and sleep apnea syndrome: a safety signal from the WHO pharmacovigilance database. 2019 Feb 1;42(2). doi: 10.1093/sleep/zsy242. Authors Data from a limited number of clinical trials support the use of ER gabapentin in reducing pain by more than 50% and improving sleep in diabetic neuropathy Sandercock 2009, Sandercock 2012. A meta-analysis of trials evaluating the treatment of trigeminal neuralgia supports the use of gabapentin in the treatment of trigeminal neuralgia Yuan 2016. Most studies show that gabapentin improves slow wave sleep (“deep sleep”) and total sleep time. Two small studies showed that gabapentin may help people with primary insomnia and occasional sleep disturbance improve total sleep time and wakefulness in the morning. Central sleep apnea (CSA) is a potentially serious and under-recognized adverse reaction of opioids, baclofen, valproic acid, sodium oxybate, gabapentin, and ticagrelor. CSA may be associated with impaired sleep quality, insomnia, nonrestorative sleep, impaired quality of life, fatigue, daytime sleepiness, and increased morbidity and mortality However, American Academy of Sleep Medicine guidelines note there is limited evidence of their benefit and they may present risks when used as sleep aids. There is no clear evidence of their effects in people with obstructive sleep apnea, although they may contribute to weight gain, a known risk factor for sleep apnea. Areas of particular interest include the long-term effects of gabapentin use on sleep architecture in sleep apnea patients, the potential for developing gabapentin formulations with reduced impact on respiratory function, and the exploration of novel combination therapies that can address both pain and sleep disorders effectively. Some studies have found that gabapentin may increase slow-wave sleep, also known as deep sleep, which is crucial for physical restoration and cognitive function. Additionally, it may reduce sleep fragmentation, leading to fewer nighttime awakenings and improved sleep continuity. Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. Like baclofen, some studies have shown that gabapentin might be of interest in alcohol dependence management [2]. In this context, baclofen is linked to sleep apnea syndrome [3, 4], aggravating sleep-disordered breathing by depressing central ventilatory drive and/or increasing upper airway obstruction. Now, let’s explore the relationship between gabapentin and sleep apnea. Does Gabapentin cause sleep apnea? Gabapentin is a medication that is commonly used to treat seizures, nerve pain, and other conditions. It works by affecting certain chemicals in the brain that may be involved in causing seizures and pain.
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