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Rare but serious gabapentin side effects include mood changes in children. It can also cause suicidal thoughts or behaviors in children and adults. If you or your child experience changes in behavior or mood while taking gabapentin, contact your prescriber immediately. NSAIDs have the most potential for risk when it comes to your kidneys. The best pain med for you depends on a variety of factors, including kidney health. Let's discuss: Pharmacology. Gabapentin and pregabalin are commonly used first-line agents for diabetic peripheral neuropathy and other common neuropathies. Pharmacologically, both agents inhibit alpha-2-delta (α2δ) subunit of N-type voltage-gated calcium channels, a key receptor involved in regulating the excitability of neurons. 3 Peripheral nerve injury results in the upregulation of α2δ-1 receptors Gabapentin is a commonly prescribed medication for the treatment of various conditions, including epilepsy, neuropathic pain, and restless legs syndrome. However, concerns have been raised about its potential impact on the liver and kidneys. Twenty-six million Americans have chronic kidney disease and most don't know it. If you don't know how well your kidneys are working, you may not realize that certain medications could be damaging your kidneys and other parts of your body. Both prescription and over-the-counter medications are filtered by the kidneys. “You ought to know these numbers because chronic kidney disease is one of the strongest risk factors for cardiovascular disease and because many medications that are taken by older people are cleared by the kidneys and can, in some cases, cause harm or worsen preexisting kidney disease,” Coca says. Gabapentin is frequently used as an analgesic in patients with chronic kidney disease. Although gabapentin is well known for its favorable pharmacokinetics, it is exclusively eliminated renally, and patients with chronic kidney disease are at risk for toxicity. Existing literature on such risk is lacking. Medications that are harmful to the kidneys are called nephrotoxic medications. Some of these medications only slightly worsen kidney function, while others could cause more serious injury. Your risk for kidney damage depends on your individual health conditions and the medication (s) you’re taking. Search is powered by a third party. Is gabapentin bad for my kidneys? In rare instances, gabapentin can cause a severe allergic reaction that can damage the liver and kidneys . Those with existing kidney problems may need a lower dose of gabapentin. This is why we must take special care with its dosage, with concomitant medications and the patient’s co-morbidities, and why, after prescribing gabapentin, we must be watchful for any signs of muscle toxicity or kidney failure and quickly discontinue the drug if necessary. Gabapentin is widely used in the management of pain. It is entirely excreted through the renal system so this needs to be considered in any patient becoming acutely ill and developing renal failure. We describe a patient who developed significant deterioration in her conscious level due to iatrogenic gabapentin overdose. Conclusion. Gabapentin (Neurontin) usually isn’t bad for your liver or kidneys. In most cases, it has little effect on these organs. In rare instances, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome. Twice a day helps neuropathy, also helps blood sugar and protects the kidney. When it comes to gabapentin and kidney disease, kidney disease sufferers should be aware of the risks that are involved in taking gabapentin with kidney disease. Gabapentin is actually toxic to the kidneys. Gabapentin is frequently used as an analgesic in patients with chronic kidney disease. Although gabapentin is well known for its favorable pharmacokinetics, it is exclusively eliminated renally, and patients with chronic kidney disease are at risk for toxicity. Existing literature on such risk is lacking. Patients with chronic kidney disease often receive inappropriately high gabapentin dosage for their kidney function, occasioning overt toxicity; advanced age and comorbidity predispose these patients for toxicity. Majority drugs, including Gabapentin, are eliminated by the kidneys and will accumulate to a toxic level in renally compromised patients as in this case. Per Lexicomp, Gabapentin’s recommended dose in patients with renal impairment is as follows: CrCl >15 to 29 mL/minute: 200 to 700 mg once daily. CrCl 15 mL/minute: 100 to 300 mg once daily Gabapentin itself won’t directly worsen kidney disease. However, incorrect dosages or accumulation due to kidney impairment can cause serious side effects that indirectly compromise overall health, potentially affecting kidney function management. In summary, gabapentin can be used in patients with stage 3 kidney disease, but only under careful medical supervision and with appropriate dosage adjustments. Never attempt to self-medicate or adjust dosages without consulting your doctor. The short answer is: yes, gabapentin can be problematic for individuals with kidney failure and chronic kidney disease (CKD). While gabapentin is often prescribed for pain management, particularly nerve pain, and sometimes for seizures, its primary elimination pathway is through the kidneys.
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