is neurontin used to treat cough neurontin 300 mg what is it used for

Effective treatments for refractory chronic cough that target these areas include behavioural treatment such as speech pathology and pharmaceutical treatment with neuromodulating medications such as gabapentin. Possible action mechanisms of baclofen and gabapentin in the treatment of refractory gastroesophageal reflux-induced chronic cough. Baclofen inhibits acid reflux as well as nonacid reflux by modulating transient lower esophageal sphincter relaxations; both baclofen and gabapentin have nonspecific central antitussive effect by acting hypersensitive cough center (nucleus tractus solitarius Gabapentin is effective in the treatment of chronic refractory cough in both subjective and objective evaluations, and its safety is better than other neuromodulators. Keywords: Chronic refractory cough, Gabapentin, Meta-analysis, Efficacy, Safety. 1. Introduction. Amitryptiline and gabapentin for example have been shown to have some effect in reducing idiopathic cough [33,52]. The use of gabapentin in chronic cough is reviewed in this series [53]. The mechanisms of action of amitriptyline and gabapentin as treatment for neuropathic pain are likely related to their central anti-nociceptive actions. In my experience, effective treatment (cure) of neurogenic cough requires use of medicines that stabilize nerve function, namely, amitriptyline (Elavil) and gabapentin (Neurontin). Neuromodulating medications, such as gabapentin, amitriptyline, pregabalin, and baclofen, have been used to treat chronic neurogenic cough. Gabapentin. A randomized, double-blinded, placebo-controlled trial by Ryan et al. evaluated the efficacy of gabapentin for improvement in cough severity and cough-related quality of life. 3 Inclusion and Because patients with chronic cough have a central hypersensitivity similar to that of neuropathic pain , gabapentin is also used to treat refractory chronic cough . Well-designed clinical trials have demonstrated that gabapentin at doses ranging from 300 to 1800 mg/day for 8 weeks significantly improves symptoms and quality of life in patients As pain and cough share the remarkably similar pathways, gabapentin, traditionally used in treatment of neuropathic pain, was recently used as a non-specifc antitussives for chronic idiopathic cough 15, 17, 19. Gabapentin has a similar lipophilic structure to the neurotransmitter gamma aminobutyric acid which notoriously performs central action 20. Introduction Gabapentin, a neurotransmitter modulator, is thought to treat refractory cough associated with interstitial lung disease by improving cough hypersensitivity. Methods/design This is a single-center, prospective, randomized, double-blind, placebo-controlled trial. The trial will investigate the effect of a 10-week course of oral gabapentin 900 mg/day on refractory cough associated 62 patients were randomly assigned to gabepentin (n=32) or placebo (n=30) and ten patients withdrew before the study end. Gabapentin significantly improved cough-specific quality of life compared with placebo (between-group difference in LCQ score during treatment period 1·80, 95% CI 0·56–3·04; p=0·004; number needed to treat of 3·58). If chronic cough persists even after treatment of the underlying disease, or if the chronic cough is not attributable to any cause, then a symptomatic approach with neuromodulators may be considered, with gabapentin as the first choice, and opioids or macrolides as alternatives. Neuromodulators are most often the first-line treatment for unexplained chronic cough. Although this is an off-label use, these drugs are thought to lessen the increased neural sensitization that underlies many cases of chronic cough. 16 Currently, there is evidence that amitriptyline, gabapentin, pregabalin, tramadol, and baclofen may benefit

is neurontin used to treat cough neurontin 300 mg what is it used for
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