Gabapentin was discontinued and his lower extremity swelling improved over subsequent days. Incidence of pedal edema with gabapentin use is approximately 7 to 7.5% with all studies being in elderly patients receiving doses above 1200 mg/day. In short, gabapentin can both alleviate certain types of leg discomfort and also contribute to a range of problems, including swelling, weakness, and even an increased risk of blood clots in the legs. The impact is multifaceted, varying greatly between individuals and dependent on factors like dosage, pre-existing conditions, and age. being unremarkable. Gabapentin was discontinued and his lower extremity swelling improved over subsequent days. Incidence of pedal edema with gabapentin use is approximately 7 to 7.5% with all studies being in elderly patients receiving doses above 1200 mg/day. This case illustrates that lower doses of gabapentin can also cause this adverse effect. Amlodipine (Norvasc), gabapentin (Neurontin, Horizant, Gralise), and pregabalin (Lyrica) can cause puffy legs and ankles. Birth control pills, certain over-the-counter pain medications, and steroids are a few other culprits. We study how severe was Foot, leg, and ankle swelling, when it was recovered, drug effectiveness, race, and more among people who take Gabapentin (gabapentin). This phase IV clinical study is created by eHealthMe based on reports submitted to eHealthMe, and is updated regularly. Although gabapentin is generally well tolerated, 1 potential reported adverse effect is peripheral edema. However, due to the extensive number of etiologies of peripheral edema, medication causes may be overlooked on an inpatient psychiatric unit. I take 600 mg of gabapentin, 300 mg twice daily. No swelling in my feet. I still get some cramping and stabbing. I hope everything is going well with others. Leg edema might be occurred in systemic and local types. Systemic edema could be caused by congestive cardiac failure, renal failure, hypoalbuminemia, protein losing neuropathy. For localized edema we can note following reasons such as primary and secondary lymphedema, lipedema, deep vein thrombosis and chronic venous disease.[ 13 , 14 ] Background. Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of indications both Food and Drug Administration approved and off-label. 1-3 It is approved by the Food and Drug Administration to treat postherpetic neuralgia and epilepsy 4 with common off-label indications including fibromyalgia, anxiety, mood disorders, and I have swelling in my legs caused by lymphedema and have to wear compression socks but mine was not caused by a medication. I also would be concerned if it's been over 5 months since stopping gabapentin and the swelling and pain is still in the hands and feet. Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect of another drug. Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Elevate your legs: If you experience swelling in the legs or feet, elevating them while sitting or lying down can help alleviate edema. Prop them up on a cushion or pillow to encourage fluid drainage. Swelling in the feet and ankles. Patients taking Neurontin may experience swelling in the feet and ankles. The presence of lower leg swelling may cause discomfort and impair walking. My mother-in-law was unable to wear regular shoes because of swelling of her feet and ankles, so we found her socks and soft slippers that fit her feet comfortably. He noticed significant leg swelling almost immediately upon starting treatment; this persisted for nearly three weeks before gradually improving after his doctor reduced his dosage. These cases highlight how individual responses vary widely based on dosage levels and personal health backgrounds while using gabapentin. This case illustrates that gabapentin induced leg swelling can confound the clinical picture and it is thus important to recognize this side effect of gabapentin. CONCLUSIONS: Due to extensive etiologies of peripheral edema, medications can often be overlooked subjecting the patients to unnecessary testing and treatment. In the literature, pregabalin-induced peripheral edema is dose-dependent [4] whereas it is less pronounced for gabapentin [29], [30], [31]. Gabapentin has non-linear pharmacokinetics, so the dose-ADR relationship is likely to be attenuated. Indeed, due to its saturable absorption, high plasma exposure values are more difficult to obtain [32 This is when you experience swollen tissues in the body, often in the arms and legs. Up to 8% of people report edema with gabapentin clinical studies. But it’s more likely to occur in older adults. My feet were swollen the first week. Will swelling go away while taking gabapentin 200 mcg at bedtime. I was on this medication for quite awhile and it did cause a lot of swelling. Then I started gaining weight and I was tired all the time. I had many other bad side effects so I’m tapering off it now. I wish that I had never started taking it.
Articles and news, personal stories, interviews with experts.
Photos from events, contest for the best costume, videos from master classes.
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |