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Do not use more than the recommended dose of gabapentin, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal supplements, that you are taking to avoid potential interactions. Drug Interactions Medications that may interact with gabapentin. Gabapentin can interact with several medications, leading to different effects. Gabapentin is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients and avoid abrupt withdrawal. Reduce dose in renal impairment. Dosing : There are a number of drugs that should not be taken with gabapentin, including certain antibiotics, antifungal medications, and drugs used to treat seizures. In some cases, taking these drugs with gabapentin can increase the risk of side effects or make the gabapentin less effective. Gabapentin is ineffective in absence seizures and should be used in caution in patients with mixed seizure disorders involving absence seizures. Gabapentin has been associated with drug reaction with eosinophilia and systemic symptoms (DRESS), otherwise known as multi-organ hypersensitivity. What medications should be avoided with gabapentin? Medications that should generally be avoided with gabapentin include opioids, benzodiazepines, and certain antidepressants. These combinations can lead to increased sedation and other serious side effects. Always consult your healthcare provider for personalized advice. How do drug Drug-food and drug-drink interactions: Food and drinks can change how medicines work or worsen side effects when they are combined. Examples include beverages like grapefruit juice and statins causing muscle pain, or alcohol and opioids leading to dangerously slowed breathing. Do not stop using gabapentin suddenly, even if you feel fine. You should not take gabapentin if you are allergic to it. To make sure this medicine is safe for you, tell your doctor if you have ever had: kidney disease (or if you are on dialysis). Some people have thoughts about suicide while taking seizure medicine. Neurontin drug interactions. There are 270 drug interactions with Neurontin (gabapentin). Neurontin alcohol/food interactions. There is 1 alcohol/food interaction Are there any serious interactions with gabapentin and other medications? Serious breathing problems can happen if you take gabapentin with drugs that cause severe sleepiness or decreased awareness. Some examples include narcotic opioids, anti-anxiety medicines, antidepressants, and antihistamines. The current work is targeted to review the risks of gabapentin misuse, its potential interactions with other drugs, side effects and use contraindications. This review consists of a total of 99 biographical references (from the year 1983 to 2016). Gabapentin and pregabalin are members of a class of anti-convulsive and anti-epileptic drugs called gabapentinoids. Gabapentin was first approved in 1993 and pregabalin followed in 2004. They’ve been widely prescribed to treat certain types of pain as well. Conditions gabapentin and pregabalin are approved to treat include: Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as gabapentin can lead to serious side effects including respiratory distress, coma, and even death. There are 4 disease interactions with gabapentin. Major Potential Hazard, Moderate plausibility. Applicable conditions: Drug Abuse/Dependence. Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Gabapentin Drug Interactions. by Carol Parker on . May 15, 2012. Tweet. Taking gabapentin together with other medications can lead to drug interactions. Some of the Gabapentin is a prescription drug most commonly prescribed to relieve nerve pain following shingles in adults and the pain of postherpetic neuralgia. Learn about side effects, drug interactions, dosages, warnings, and more. Gabapentin should not be mixed with any other illicit drugs, alcohol, or certain prescription medications like hydrocodone and morphine. If you’re considering taking an over-the-counter medication while on gabapentin, discuss it with your doctor before making a decision. Myasthenia Gravis: Gabapentin is contraindicated in individuals diagnosed with myasthenia gravis, an autoimmune disease that causes muscle weakness. Myoclonus: The medication is also contraindicated in patients with myoclonus, a neurological disorder characterized by sudden, involuntary muscle jerks.
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