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Since early reports in the 1930s and 1940s, 7 quinine and its derivatives have been the mainstay of therapy for idiopathic muscle cramps. However, a United States Food and Drug Administration (FDA) Federal Register statement released on December 15, 2006, ordered unapproved quinine drugs to be removed from the market and cautioned consumers about their “off-label” use, citing “665 Please, a simple answer. Can Gabapentin cause leg cramps? I take 300 mg gabapentin in the morning, 200 mg at lunch and 200 at dinner. Last night I had a leg cramp so severe it rolled me off the bed and lasted for about 5 minutes. Enough pain to make a grown man want to cry. I was concerned that going back to sleep might trigger the cramp again. Several other medications have been used in clinical practice to manage muscle cramps, including the anticonvulsants gabapentin (Neurontin), carbamazepine (Tegretol), and oxcarbazepine (Trileptal). On and off. Last evening I took 400mg for the RLS. I woke up screaming in pain with cramp from knee to foot. I have suspected the Gabapentin but now I k now. I will stop it. Another thing that causes muscle cramps is Chlorthalidone for high BP. Gabapentin is used to control seizures, to treat nerve pain that can happen after having had shingles, and to treat a condition called restless legs syndrome. In addition to these FDA-approved uses, doctors sometimes prescribe gabapentin off-label. Nocturnal leg cramping was increasing with my age to the point where every night my sleep was disturbed up to several times with painfull and long lasting cramps in calves, feet, and toes. I was put on carbamazepine with positive results for a short period of time and then the cramps returned. Yes, unfortunately the severe side effects of Neurontin (Gabapentin) is: numbness of an arm or leg; one-sided weakness; swelling of the hands, legs, or feet. Read more: Sometimes, leg cramps happen for no reason, but other times, they could be a sign or symptom of a health condition. “Secondary” leg cramps are a symptom or complication of a more serious health condition. If you have any of the following conditions, your leg cramps may be a result of that condition. Despite the lack of a universally recognized therapy for nighttime leg cramps, a few approaches may be worth trying. Few things are more jarring to a night's sleep than shooting calf pains. If you have nocturnal leg cramps, you have lots of company. Although they can strike people at any time of life, they become more common with age. Carisoprodol (Soma), diltiazem, gabapentin (Neurontin), magnesium, orphenadrine (Norflex), verapamil, and vitamin B 12 complex may be useful in some patients with nocturnal leg cramps. Leg cramps Gabapentin significantly increased the CTF, returning it to normal values. With the limitation of an open-label methodology, our clinical and neurophysiologic experience suggests that a gabapentin dose of 600-1200 mg/d would be helpful in the treatment of muscular cramps. Gabapentin’s calming effects on the nervous system might help improve sleep quality for those suffering from nighttime leg cramps or other painful episodes. Adjunct Therapy For individuals already taking medications for other conditions—such as neuropathy—gabapentin might serve as an effective adjunct therapy.
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