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Background. Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of indications both Food and Drug Administration approved and off-label. 1-3 It is approved by the Food and Drug Administration to treat postherpetic neuralgia and epilepsy 4 with common off-label indications including fibromyalgia, anxiety, mood disorders, and Rare but serious gabapentin side effects include mood changes in children. It can also cause suicidal thoughts or behaviors in children and adults. If you or your child experience changes in behavior or mood while taking gabapentin, contact your prescriber immediately. When you stop taking gabapentin, you'll need to reduce your dose gradually to avoid withdrawal symptoms. Do not stop taking gabapentin without talking to your doctor. Talk to your doctor if you're concerned about becoming physically dependent on gabapentin. Other side effects. These are not all the side effects of gabapentin. Sorry to say, but my swelling lead to weight gain.I was prescribed Gabapentin for nerve pain. I started at 200 mgs once daily at bedtime. I couldn't stay on it for longer than two weeks. Gabapentin is an anticonvulsant medication that doctors often prescribe to prevent seizures in people with epilepsy. Learn about its side effects here. swelling in the legs or feet from fluid Learn about the side effects of Neurontin (gabapentin), from common to rare, for consumers and healthcare professionals. Swelling in the feet and ankles. Patients taking Neurontin may experience swelling in the feet and ankles. The presence of lower leg swelling may cause discomfort and impair walking. My mother-in-law was unable to wear regular shoes because of swelling of her feet and ankles, so we found her socks and soft slippers that fit her feet comfortably. Elevate your legs: If you experience swelling in the legs or feet, elevating them while sitting or lying down can help alleviate edema. Prop them up on a cushion or pillow to encourage fluid drainage. Seven days after the administration of the gabapentin, the patient complained from pain and edema and scaling and hyperesthesia in his lower extremities and pitting edema, pain and tenderness. I have swelling in my legs caused by lymphedema and have to wear compression socks but mine was not caused by a medication. I also would be concerned if it's been over 5 months since stopping gabapentin and the swelling and pain is still in the hands and feet. This is clinically important as gabapentin is a very commonly prescribed medication to patients with neuropathies, especially in diabetic neuropathy who may also have other co-morbid condition such as heart failure, malnutrition, nephropathy, that can give rise to bilateral leg swelling. this adverse effect. It is important to recognize this adverse effect because gabapentin is used in conditions like diabetic neuropathy, which is associated with multiple co-morbidities that can give rise to bilateral leg swelling. Presence of gabapentin induced leg swelling can thus confound the clinical picture. Key words: He noticed significant leg swelling almost immediately upon starting treatment; this persisted for nearly three weeks before gradually improving after his doctor reduced his dosage. These cases highlight how individual responses vary widely based on dosage levels and personal health backgrounds while using gabapentin. We present a rare case of gabapentin induced bilateral 3+ pitting edema in a young man with sensorimotorpolyneuropathy, making it an unusual presentation. Paxlovid has a drastic effect on kidney function and I gained about 20 lbs in less than two weeks. However, this morning, I was down by 6 lbs, which is a step in the right direction (at last!). When I was first prescribed gabapentin, I was told to take 300 mg three times a day. Medications are a common reason for swollen ankles and feet, also called pedal edema. Amlodipine (Norvasc), gabapentin (Neurontin, Horizant, Gralise), and pregabalin (Lyrica) can cause puffy legs and ankles. Birth control pills, certain over-the-counter pain medications, and steroids are a few other culprits. This case illustrates that gabapentin induced leg swelling can confound the clinical picture and it is thus important to recognize this side effect of gabapentin. CONCLUSIONS: Due to extensive etiologies of peripheral edema, medications can often be overlooked subjecting the patients to unnecessary testing and treatment. A very small percentage of people taking Neurontin may experience swelling of the hands, feet, ankles, or other extremity locations. Shallow or labored breathing may also occur. These are potentially life threatening reactions and medical help should be sought immediately. Although gabapentin is generally well tolerated, 1 potential reported adverse effect is peripheral edema. However, due to the extensive number of etiologies of peripheral edema, medication causes may be overlooked on an inpatient psychiatric unit. Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect of another drug.
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