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Gabapentin is a unique anticonvulsant that is used as adjunctive therapy in management of epilepsy and for neuropathic pain syndromes. Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from gabapentin have been reported. In this paper, we describe the demographic, clinical characteristics, and outcomes in individuals with liver injury due to AEDs who were enrolled into the DILIN Prospective Study. Detailed Gabapentin dosage information for adults and children. Includes dosages for Restless Legs Syndrome, Epilepsy and Postherpetic Neuralgia; plus renal, liver and dialysis adjustments. Herein, we report a gabapentin-induced hepatocellular injury in a patient without another identifiable cause for acute liver injury. Discontinuing gabapentin resulted in rapid reversal improvement in hepatocellular injury. Gabapentin, which has been FDA-approved for the treatment of postherpetic neuralgia in adults, is commonly used for this disorder. Gabapentin, a water-soluble amino acid, is eliminated unchanged Gabapentin is an uncommon cause of DILI reported to cause a hepatocellular, cholestatic, or mixed picture of liver injury. Given the limitations of prior cases, we feel our report most closely ties gabapentin use to the resultant transaminase elevation. Gabapentin is not metabolized by the liver. Instead, it is excreted unchanged in your kidneys after circulating in your blood. Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. Gabapentin and Cirrhosis of the Liver - Fatty Liver Disease Note: This document provides detailed information about Neurontin Side Effects associated with gabapentin. Some dosage forms listed on this page may not apply specifically to the brand name Neurontin. Applies to gabapentin: oral capsule, oral solution, oral suspension, oral tablet, oral tablet extended release 24 hr. Serious side effects of Changes in liver function may be attributed to free radical damage induced by gabapentin, as documented in this study, where the drug enhanced antioxidant defense systems and elevated liver NO A new study suggests that gabapentin could provide greater benefit than FDA-approved drugs for patients with alcohol-associated liver disease. Learn about the potential effects of Gabapentin on your liver and kidneys. Find out if it is safe to use and how to protect your organs while taking this medication. We can help! The most common gabapentin (Neurontin) side effects are dizziness and drowsiness. This may affect your ability to drive or perform other activities. Other gabapentin side effects include edema (fluid buildup), weight gain, and eye problems, but these aren’t as common. Rare but serious gabapentin side effects include mood changes in children. Gabapentin-Induced Liver Toxicity Am J Ther. 2022 Nov-Dec;29(6):e751-e752. doi: 10.1097/MJT.0000000000001208. Epub 2020 Jun 5. Authors Japjot Chahal 1 In an effort to facilitate safe pain control, this article will summarize the existing literature regarding impaired pharmacokinetics due to liver dysfunction and dosing recommendations for analgesic treatment in patients with cirrhosis. Gabapentin (Neurontin) usually isn’t bad for your liver or kidneys. In most cases, it has little effect on these organs. In rare instances, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome. Gabapentin enacarbil and gabapentin are associated with a low rate of transient serum enzyme elevations during treatment and with rare instances of clinically apparent liver injury. Gabapentin enacarbil is a long acting form of gabapentin that is used for restless leg syndrome and for painful postherpetic neuropathy. Gabapentin induced liver injury is rare with few reported cases, many of which did not exclude other etiologies. In this case, the key elements of diagnosing DILI were met including gabapentin initiation closely preceding liver injury, other etiologies excluded, and discontinuation of gabapentin leading to improvement. RETRACTED: Vitamin E protects against gabapentin-induced chronic hepatic and renal damage associated with the inhibition of apoptosis and tissue injury in rats Author links open overlay panel Nermeen N. Welson a , Remon R. Rofaeil b c , Sabreen Mahmoud Ahmed d , Shereen S. Gaber e , Gaber El-Saber Batiha f , Mary Girgis Shahataa g Gabapentin-Induced Liver Toxicity. Chahal, Japjot MD 1; Arif, Muhammad Osman MD 2; Achufusi, Ted George MD 1. Author Information . 1 Internal Medicine, SUNY Upstate
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