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Gabapentin. Gabapentin is an anticonvulsant (an analogue of gamma-aminobutyric acid). It is approved to treat neurological disorders such as seizures and neuropathic pain. Research: A systematic review has confirmed that Gabapentin 900mg per day reduces hot flushes more effectively than placebo 11. The most common side effect of gabapentin is Gabapentin (Neurontin, Gralise, others). This antiseizure medicine helps ease hot flashes. Side effects can include being drowsy, dizzy or tired and swelling in the arms and legs, called edema. Pregabalin (Lyrica). This is another anti-seizure medicine that can help ease hot flashes. Overall, gabapentin was found to reduce the frequency of hot flushes at both 4 and 12 weeks (mean difference: -1.62 [95% CI: -1.98 to -1.26], and -2.77 [95% CI: -4.29 to -1.24], respectively). 28 Among the two crossover studies reported in the meta-analysis, there was no statistically significant difference between the use of gabapentin and Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. Gabapentin for menopausal symptoms Menopause is a normal event, but some women have troublesome symptoms such as hot flushes and night sweats. The most effective treatment is menopausal hormone therapy (MHT). Gabapentin is a non-hormonal treatment that may be prescribed for women who need, or want, to avoid MHT. Government of Western Australia Gabapentin is effective in reducing the frequency and severity of hot flashes, particularly for those experiencing menopausal symptoms. Originally used for epilepsy and neuropathic pain, it has been found to offer significant relief from hot flashes. Key Benefits: Hot flashes are a common symptom of menopause, affecting approximately 75% of women. Navigating menopause can be challenging, with symptoms like hot flashes, mood swings, and sleep disturbances affecting daily life. While hormone replacement therapy is a common treatment, some women seek alternatives. Gabapentin, traditionally used for nerve pain, has emerged as a promising option for managing menopaus Objective: To review the literature examining the use of gabapentin for treatment of hot flashes during natural or surgically induced menopause. Data sources: A literature search was conducted via PubMed, MEDLINE, and International Pharmaceutical Abstracts (1948-November 2010) using the search terms gabapentin, hot flashes, and menopause. earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and Step-wise approach to management of menopausal hot flashes. M ANAGEMENT. The management of HFs is guided by their frequency and severity. The severity of HFs can be graded as (a) mild (no interference with usual daily activities), (b) moderate (interfere with usual daily activities to some extent), and (c) severe (when usual daily activities cannot be performed).[] Gabapentin has been shown to reduce hot flashes in women with breast cancer and in those with chemically or surgically induced menopause, or both, as well as in a small sample of women in natural menopause. Gabapentin seems to be a safe and well-tolerated drug, and it is currently licensed for use for the treatment of epilepsy. While gabapentin may offer relief for some women struggling with menopause-related sleep issues, it’s important to consider a range of approaches to addressing this common problem. Many women prefer to explore non-pharmacological options before turning to medication, and even those who choose to use gabapentin may benefit from incorporating Gabapentin is a drug that doctors sometimes prescribe off-label to reduce hot flashes during menopause. Instead of affecting hormones, experts think it may act on the hypothalamus, the part Numerous reports in the medical literature and popular media have discussed the effectiveness of various nonhormonal agents in reducing menopausal hot flash symptoms. Data for these therapies The North American Menopause society and the American College of Obstetricians and Gynecologists recommend the use of gabapentin as an option for managing hot flashes in women who are unwilling to take estrogen-containing supplements. Although the FDA has not approved Neurontin for hot flashes, there’s some good evidence that it’s effective. A study from the University of Rochester showed that gabapentin was effective in reducing hot flashes in patients with a damaged hypothalamus, and there have been over 20 studies on menopausal women that show similar results.
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