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Despite the statistical associations and the pathophysiological hypotheses suggested here, this list of suspected drugs has to be considered with caution given the alternative causes that can be responsible for thrombocytopenia, and particularly for the rarest associations. We report a case of a patient who had thrombocytopenia with the dose of 2400 mg/day of gabapentin. The causal relationship between gabapentin and thrombocytopenia was revealed by dramatic Thrombocytopenia is defined as a platelet count below the 2.5th lower percentile of the normal platelet count distribution. Results of the third US National Health and Nutrition Examination Survey (NHANES III) support the traditional value of 150 × 10 9 /L as the lower limit of normal. 1 However, platelet counts between 100 and 150 × 10 9 /L do not necessarily indicate disease if they have Gabapentin is eliminated from the systemic circulation by renal excretion as unchanged drug. Gabapentin is not appreciably metabolized in humans. Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosing. Gabapentin elimination rate constant, plasma clearance, and renal clearance are directly Europe PMC is an archive of life sciences journal literature. Five clinical criteria have been proposed to help physicians to determine the diagnosis of DITP 1: 1) exposure to new drugs 5-10 days before onset of thrombocytopenia; 2) recovery from thrombocytopenia after discontinuing the candidate drug; 3) other drugs were continued or reintroduced after discontinuation of the candidate drug with a Many drugs have been implicated in drug-induced immune thrombocytopenia (DITP). Patients with DITP develop a drop in platelet count 5 to 10 days after drug administration with an increased risk of hemorrhage. Drug-induced thrombocytopenic purpura should be suspected when a patient, child or adult, has sudden, severe thrombocytopenia. Drug-induced thrombocytopenic purpura is even more strongly suspected when a patient has repeated episodes of sudden, severe thrombocytopenia. KEY WORDS: Haemolytic anaemia, petechiae, thrombocytopenic purpura We report a case of a patient who had thrombocytopenia with the dose of 2400 mg/day of gabapentin. The causal relationship between gabapentin and thrombocytopenia was revealed by dramatic increase in thrombocyte count following the cessation of the gabapentin treatment. Analgesic therapy using small doses of gabapentin gave a pronounced, stable positive effect (pain intensity statistically significantly decreased by an average of 50%). After 7 days of gabapentin therapy, a decrease in the opioid dose was noted in 52% of patients. Side effects were dominated by drowsiness 67% ( n = 16), dizziness 32% ( n = 8). Drug-Induced Immune Thrombocytopenia Results of the Testing for Drug-Dependent Platelet-Reactive Antibodies by the BloodCenter of Wisconsin Data are from 1995-2018, provided with the permission of Daniel Bougie PhD, Janice McFarland MD, Brian Curtis, PhD and Richard Aster, MD This topic review discusses drug-induced immune thrombocytopenia (DITP), in which the mechanism involves antibody-mediated platelet destruction caused by exposure to a drug that leads to isolated thrombocytopenia (without anemia or leukopenia). Thrombocytopenia is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Revlimid, and have Multiple myeloma. Adverse Gabapentin Effects in pregnant women. Gabapentin (Neurontin) has been assigned a pregnancy category of c. C is typically classified as a passing grade. Not so with pharmaceuticals. What this grade implies is that the drug has been demonstrated as Teratogenic (deformity promoting), and fetotoxic (dangerous to the foetus) Rare (less than 0.1%): Thrombocytopenia, thrombophlebitis, leukocytosis, lymphocytosis, Gabapentin side effects can vary depending on the individual. Always A 33-year-old man developed thrombocytopenia during treatment with gabapentin for complex partial seizures [duration of treatment/time to reaction onset not stated]. The man, who had been diagnosed with epilepsy at the age of 15 years, had received many different medications, none of which had successfully controlled his seizures. The AERS database contained reports of thrombocytopenia for 2062 agents; 1444 (70%) met our inclusion criteria of currently approved drugs. These 1444 drugs included 327 (93%) of the 351 drugs that were described in case reports and/or tested for drug-dependent antibodies; 24 (7%) of the drugs described in case reports and/or tested for drug-dependent antibodies were not identified in the AERS We suggest caution when considering gabapentin for patients with preexisting low platelet counts, as there seems to be a risk for worsening thrombocytopenia with this antiepileptic in the presence of HIV infection. Gabapentin has become increasingly used in psychiatric practice specifically for anxiety disorders. Gabapentin, a structural analog of gamma-aminobutyric acid, is used to treat peripheral neuropathic pain. Here we report the first case of platelet function disorder associated with gabapentin treatment in a 44-year-old woman without a history of bleeding. The repeated exposure with a time-linked and reversible decrease in platelets indicates an association between gabapentin and thrombocytopenia in this patient with HIV. It is possible that HIV-induced thrombocytopenia may have a sensitizing effect on the action of gabapentin.
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