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The best part? Gabapentin is generally well-tolerated and has minimal side effects compared to hormonal therapies. It’s a non-hormonal option that can be a game-changer for women who are seeking relief from menopause symptoms without the risks associated with hormone replacement therapy. If you’re tired of suffering through menopause In my previous post I reviewed the various nonhormone therapies that are effective for hot flashes in menopause and I’ve also recently covered one of them, the new prescription medication called fezolinetant, in detail here. Dietary supplements people often use for menopause symptoms include: Plant estrogens. Some plants have substances that are like the hormone estrogen. Examples are soy, red clover and flaxseed. But studies most often have found that plant estrogens help menopause symptoms little or not at all. Research is ongoing. Black cohosh. How Does Gabapentin Help With Menopause? Experts theorize that gabapentin functions primarily by acting on the hypothalamus, which regulates body temperature, rather than directly affecting hormones. The FDA has not approved gabapentin for hot flashes, but clinical studies have demonstrated its effectiveness in reducing their frequency. Gabapentin is a drug that doctors sometimes prescribe off-label to reduce hot flashes during menopause. Instead of affecting hormones, experts think it may act on the hypothalamus, the part of Although the FDA has not approved Neurontin for hot flashes, there’s some good evidence that it’s effective. A study from the University of Rochester showed that gabapentin was effective in reducing hot flashes in patients with a damaged hypothalamus, and there have been over 20 studies on menopausal women that show similar results. • Antacids – medicines used to treat heartburn or reflux (reduces the effectiveness of gabapentin if taken less than 2 hours apart). • Alcohol – combining gabapentin and alcohol can make you more sleepy, dizzy or light-headed. Your doctor may suggest you avoid alcohol while you are being treated with this medicine. How to take gabapentin 1. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is The use of gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women by 20% to 30%, but the high level of heterogeneity across the studies precluded the provision of a reliable summary effect. Non-hormonal treatments for hot flashes include the use of certain antidepressants (Celexa ®, Lexapro ®, Brisdelle ®, Lyrica ®, and Effexor ®) and medications that act on the central nervous system such as gabapentin (Neurontin ®) and pregabalin (Lyrica ®). An investigational nonhormonal drug, extended-release gabapentin, effectively improved sleep and reduced hot flashes in menopausal women. Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. Gabapentin, known by its brand name Neurontin, is primarily used to treat conditions like epilepsy and neuropathic pain. However, it has been found to be effective in alleviating hot flashes. Gabapentin works by mimicking the neurotransmitter gamma-aminobutyric acid (GABA). The North American Menopause society and the American College of Obstetricians and Gynecologists recommend the use of gabapentin as an option for managing hot flashes in women who are unwilling to take estrogen-containing supplements. To evaluate the efficacy and safety of gabapentin for the treatment of hot flashes in women with menopause and/or breast cancer, we performed a search of the MEDLINE database (1966-March 2008) and International Pharmaceutical Abstracts, as well as manually searching reference articles for relevant articles and abstracts; 10 clinical studies earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and in women include gabapentin, clonidine, venlafaxine or selective serotonin reuptake inhibitors (SSRIs). The treatment option depends on the individual. Gabapentin Brand name: Neurontin® available as 100mg, 300mg, 400mg, 600mg and 800mg capsules. Also available in generic brands. Gabapentin is usually used to control epilepsy or chronic Objective: To compare the effectiveness and tolerability of gabapentin with placebo for the treatment of hot flashes in women who enter menopause naturally. Other agents that have been used to alleviate hot flashes include belladonna/ergotamine tartrate/phenobarbital combination, dong quai, evening primrose oil, gabapentin, ginseng, mirtazapine • Antacids – medicines used to treat heartburn or reflux (reduces the effectiveness of gabapentin if taken less than 2 hours apart). • Alcohol – combining gabapentin and alcohol can make you more sleepy, dizzy or light-headed. Your doctor may suggest you avoid alcohol while you are being treated with this medicine. How to take gabapentin 1.
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