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This article will explore the characteristics, efficacy, side effects, and considerations for choosing between gabapentin and pregabalin. Understanding Neuropathic Pain Definition and Causes : Neuropathic pain is characterized by pain arising from nerve damage or dysfunction. Gabapentin is contraindicated in individuals who have hypersensitivity to this medication or its components, which can cause fever and other symptoms that could become severe. Pregabalin vs Gabapentin â What is the Difference? Pregabalin and gabapentin can both provide relief from pain and be effective ways to manage seizure disorders. A few studies have found that pregabalin has fewer side effects and may be more efficacious for neuropathic pain than gabapentin. Several studies reviewing conversion of gabapentin to pregabalin predict that a rough ratio for conversion is about 6:1 gabapentin to pregabalin. That said, differences in the occurrence rates of side effects for pregabalin and gabapentin may be less significant than available medical literature suggests. As of current, there are no convincing data to substantiate the idea that pregabalin is significantly more tolerable (i.e. causes fewer side effects) than gabapentin – or vice-versa. Pregabalin showed superior results compared to gabapentin in the Visual Analog Scale (VAS) at various time intervals up to 12–14 weeks (SMD −0.47, 95% CI −0.74 to −0.19). Side Effects: Both gabapentin and pregabalin cause similar adverse effects, such as dizziness, drowsiness, somnolence, blurred vision, dry mouth, nausea, and vomiting. Rarely, these two medications can cause serious adverse events, including allergic reactions with skin rash, hives, itching, swelling of the face, tongue, and lips, respiratory Lyrica has an average rating of 6.4 out of 10 from a total of 925 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 26% reported a negative effect. View all 2570 reviews Pregabalin starts working faster because it is absorbed more quickly than gabapentin. The common side effects of Pregabalin include dry mouth, blurred vision, headache, weight gain, indigestion, and constipation. At the same time, the common side effects of Gabapentin include – shaking, diarrhea, dizziness, drowsiness, and weakness. Common side effects include dizziness, drowsiness, and fatigue. How Do Pregabalin and Gabapentin Work? Pregabalin and Gabapentin work by affecting nerve signals in the brain to reduce pain and prevent seizures. Both medications target calcium channels in nerve cells, slowing down excessive nerve activity. What are the side effects of Lyrica vs. gabapentin? WARNING. Antiepileptic medications have been associated with increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need. Both medications have common side effects, such as drowsiness, dizziness, and edema. But pregabalin is more likely to cause weight gain. More serious side effects, such as suicidal thoughts and behaviors, heart problems, or misuse, are more rare. Gabapentin Vs Pregabalin Side Effects. The side effects of both Gabapentin and Pregabalin are similar; however, some studies indicate that Pregabalin may have a lower risk of adverse effects. Two of the most common side effects of Gabapentin and Pregabalin include sleepiness and dizziness. Yes, Lyrica (pregabalin) can cause extreme drowsiness (somnolence) and may affect your ability to drive, operate machinery, or do other dangerous activities. This may lead to an injury or fall. In studies, up to 20% of children and 35% of adults experienced drowsiness as a side effect. Gabapentin and pregabalin are similar drugs but differ in several distinct ways. The main differences are their indications—specific uses that the Food and Drug Administration (FDA) has approved them to treat—and their dosages. While both medications are effective in managing pain and anxiety, Pregabalin vs Gabapentin has a different side effect profile. Pregabalin has been shown to have a higher risk of addiction, with some users experiencing withdrawal symptoms when they try to stop taking the medication. Gabapentin: Blurred vision, weight gain, peripheral edema, dizziness, and drowsiness. Pregabalin: Similar effects but may cause mild pain, shallow breathing, and potential for abuse. Pregabalin has an average rating of 6.8 out of 10 from a total of 1667 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 23% reported a negative effect. View all 2568 reviews Thank you I really appreciate your question I have type 2 diabetes also have degenerative disc and back problems I have sciatica and legner pain and my feet burn from neuropathy I don't know the difference between the two drugs either I only have been on gabapentin and it seems to be not working quite as well even though the dose is much higher I take 600 mg three times a day my doctor The particular NNTs for pregabalin and gabapentin were 7.71 and 7.16, respectively. 10 A more recent meta-analysis in 2022 specifically focused on post-herpetic neuralgia and found greater efficacy with pregabalin in alleviating pain and improving global perception of pain and sleep. 15 Another meta-analysis published in 2021 reported similar Lyrica (pregabalin) and gabapentin are similar medications in terms of their uses, efficacy and side effect profile. It is a common misconception that gabapentin is the generic of Lyrica. This is not the case however.
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