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Gabapentin is widely used in veterinary practices as an anxiolytic in cats with the advantage of having minimal undesirable effects. 3 In humans, pregabalin has been shown to have greater potency and lipid solubility compared to gabapentin and cause greater degrees of sedation. 4, 5. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet 2010;49(10):661-669. Kukanich B, Cohen RL. Pharmacokinetics of oral gabapentin in greyhound dogs. Vet J 2011;187(1):133-135. Siao KT, Pypendop BH, Ilkiw JE. Pharmacokinetics of gabapentin in cats. Am J Vet Res 2010;71(7):817-821. VETERINARY PRACTICE GUIDELINES *These guidelines areNorth supported by generous educational grants from Arthrex Vet Systems, Boehringer Ingelheim Animal Health USA Inc., Elanco, and Zoetis. AI (artificial intelligence); CBPI (Canine Brief Pain Inventory); CMIs (Clinical Metrology Instruments); COAST (Canine OsteoArthritis Staging Tool); Although both Pregabalin and Gabapentin belong to the same class of medications (anticonvulsants), they have key differences in potency, absorption, and duration of action. Here’s how they compare: Pregabalin may be a better choice for severe cases. For immediate relief, Pregabalin might be preferable. At the doses studied, oral pregabalin and gabapentin produced indistinguishable effects as adjunctive perioperative sedation agents in cats. Keywords: cat, sedation, premedication, gabapentin, pregabalin Today the U.S. Food and Drug Administration approved Bonqat (pregabalin oral solution) for alleviating acute anxiety and fear associated with transportation and veterinary visits in cats. Bonqat Dose of Pregabalin in Dogs and Cats. Dogs: For refractory epilepsy: 3–4 mg/kg p.o. q8h, starting at 2 mg/kg and gradually increasing.; For neuropathic pain: 4 mg/kg p.o. q12h (limited evidence). One of the best uses of gabapentin is as a pre-visit pharmaceutical, along with trazodone, to reduce anxiety and stress associated veterinary visits. Pregabalin Two potential benefits of pregabalin are improved bioavailability (the amount of the drug that enters the bloodstream) and a longer half-life. Pregabalin is a neuroactive drug used to treat partial-onset (focal) seizure disorders, neuropathic pain, and anxiety in humans. Like gabapentin, a drug more commonly used in veterinary medicine for the control of seizures due to epilepsy and for neuropathic pain control, pregabalin seems to work as a close structural relative to gamma-aminobutyric acid. Objective: To compare the effects of oral pregabalin versus gabapentin on sedation quality and anesthesia recovery times in cats in a typical perioperative setting. Animals: 50 healthy cats with > 1 kg body weight presenting for elective surgery. Vet Rec 171, 501 PubMed. Dewey C W, Cerda-Gonzalez S, Levine J M et al (2009) Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy. JAVMA 235, 1442-1449 PubMed. Pregabalin became available as a successor to gabapentin and is also used to control several other neurologic conditions, including neuropathic pain, a type of pain caused by nerves. More recently, pregabalin has been useful to control anxiety in animals, especially when being transported. These include gabapentin, pregabalin, amantadine, and amitriptyline. Proposed mechanisms of action for each drug, and known pharmacokinetic profiles in dogs are discussed. Strong evidence exists in the human literature for the utility of most of these treatments, but clinical veterinary-specific literature is currently limited. Pregabalin shows higher affinity to the α2-δ protein subunit than gabapentin (5), suggesting that pregabalin is more potent than gabapentin. Humans exposed to pregabalin should seek medical advice and may experience dizziness, sleepiness, blurred vision, weakness, dry mouth, and difficulty with concentration or attention. 2. References. Zoetis is redefining the feline veterinary experience with the commercial launch of Bonqat (pregabalin oral solution) in the U.S. News release. Zoetis. The most common drugs used specifically for neuropathic pain the veterinary setting are gabapentin and pregabalin, with TCA occasionally referenced (46, 47). A summary of dosing recommendations for medications used to manage neuropathic pain in dogs can be found in Table 2. Several drugs are commonly used in the veterinary clinical setting to treat neuropathic pain. These include gabapentin, pregabalin, amantadine, and amitriptyline. Proposed mechanisms of action for each drug, and known pharmacokinetic profiles in dogs are discussed. Compared to gabapentin, pregabalin shows: A study in dogs undergoing surgery for intravertebral disc disease and received 4mg/kg of pregabalin twice a day had lower pain scores when compared to dogs that did not receive any (Schmierer et al., 2020). New OA therapies include anti-NGF mAbs (Librela), injectable tin colloid (Synovetin), and injectable collagen/elastin (Spryng). Osteoarthritis pain can be difficult to treat, but newer drugs and compounds, and some existing ones, can be used effectively either alone or as part of multimodal therapy. Compared with gabapentin, pregabalin is more potent, requires a smaller dose, and has a longer duration of action. Take-Home Points. An oral solution of pregabalin was recently approved for treatment of feline acute fear, anxiety, and stress associated with transportation and veterinary visits.
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