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And as a consequence, memory and attention and sleepiness are common side effects of these medications,” says Aatif M. Husain, M.D., a professor of neurology and the division chief of epilepsy, sleep and neurophysiology in the department of neurology at the Duke University School of Medicine in Durham, North Carolina. Fortunately, memory loss and other side effects associated with gabapentin are not considered permanent and should resolve upon discontinuation of therapy or with a dose decrease. Please reach out to your doctor regarding the side effects you are experiencing and the high doses you are taking, which are far beyond your prescribed therapy and Some studies show that gabapentin may have effects on your memory. But we need more research on this topic to be sure. Still, older adults are more at risk of memory issues and medication side effects in general. A 2022 study looked at 480 adults aged 65 and older who were taking gabapentin. Memory loss caused by Gabapentin may improve or resolve after stopping the medication, but not everyone will experience a complete recovery. Strategies such as using memory aids, practicing good sleep hygiene, exercising regularly, maintaining a healthy diet, and considering cognitive rehabilitation therapy can help manage memory issues. Gabapentin generally has mild side effects in short-term use, but the long-term use of this drug has been linked to more serious side effects, including memory loss and cognitive impairments. This has raised questions about the safety of gabapentin use and whether it can cause memory problems. Some of the most common Gabapentin long-term side effects include: Memory loss: Long-term gabapentin use has been linked to problems with memory and difficulty concentrating. Consult your physician if you have concerns about gabapentin and memory loss. When compared with the nondrug condition, both medications resulted in significantly worse performance on tests of verbal memory and motor speed, and participants reported a high incidence of sedative effects. Frequently reported side-effects for gabapentin included fatigue, unsteadiness, and dizziness. However, gabapentin seems to be different from the traditional antiseizure drugs, and the exact mechanism(s) through which gabapentin exerts both its clinical and potential side effects is still unknown. One hypothesis includes binding to the alpha2-delta subunit of the voltage-dependent calcium channel (Rose and Kam, 2002). Considering that Gabapentin use has been associated with memory loss and cognitive decline. Studies suggest that the risk of dementia may be higher in patients treated with gabapentin. It is important for patients and healthcare providers to be aware of the potential cognitive side effects of gabapentin. Memory loss, minor memory impairment can happen to those who take gabapentin. In the package insert for the drug, it mentions that mild memory loss was a side effect that certain participants got, although it wasn't that common. About 2% of those in clinical trials had some form of cognitive impairment on the drug. Rare but serious side effects of gabapentin include: rash, itching, or yellowing of the skin; swelling of the face and throat, a condition called angioedema; problems speaking or swallowing; changes in memory, ability to concentrate, or personality. Gabapentin may cause breathing problems in people who use opioid pain medicines and those with Though generally well-tolerated, gabapentin can cause side effects such as dizziness, fatigue, and coordination issues. In some cases, individuals may experience cognitive changes, such as memory loss or difficulty concentrating. Because of these potential effects, gabapentin should only be used under medical supervision. Other side effects; Professional info; FAQ; Applies to gabapentin: oral capsule, oral solution, oral suspension, oral tablet, oral tablet extended release 24 hr. Serious side effects of gabapentin. Along with its needed effects, gabapentin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they Claims against gabapentin focus on its potential to cause memory loss, particularly when used off-label for conditions not approved by the FDA, such as anxiety and bipolar disorder. Lawsuits argue that pharmaceutical companies failed to adequately warn patients about cognitive side effects. Navigating the Cognitive Maze: Managing Side Effects. For those grappling with gabapentin’s cognitive effects, all is not lost. There are strategies to help manage these side effects and maintain mental clarity while still benefiting from the medication’s therapeutic effects. Monitoring cognitive function is a crucial first step. Because of the side effects of long-term treatment with these drugs, we decided to evaluate the chronic effect of gabapentin, pregabalin and baclofen alone and in combination on rat memory using ORT. The data of this study was compared with scopolamine that induces memory deficits in ORT model ( 18 ). After a literature review, we were unsure of the duration the drugs would require to cause the side effects of cognitive impairment or dementia. We conducted a preliminary analysis, including gabapentin or pregabalin exposure period of 30 days and 90 days. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. If you have concerns about gabapentin-induced memory loss or any other side effects, consult with your healthcare provider for personalized guidance and support. “Using gabapentin safely and responsibly is crucial to minimize the risk of cognitive impairments and other adverse effects.” Common Side Effects of Gabapentin While very effective for certain indications, gabapentin unfortunately can have many adverse central nervous system effects in addition to memory loss including: Drowsiness; Dizziness; Amnesia; Memory impairment; Disorientation; Emotional Lability
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